PROGNOSTIE PARAMETERS IN ASTROEYTOMA: P53 AND C-ERB B-2 IMMUNOREAETIVITY, PCNA, AND AGNOR COUNT

Meral KOYUNCUOĞLU; Kemal YÜCESOY; Sultan CİNGÖZ; M. Şerefettin CANDA; Metin ÇABUK; Safiye AKTAŞ

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Turkish Neurosurgery 1999 , Vol 9 , Num 3-4

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PROGNOSTIE PARAMETERS IN ASTROEYTOMA: P53 AND C-ERB B-2 IMMUNOREAETIVITY, PCNA, AND AGNOR COUNT

Meral KOYUNCUOĞLU¹, Kemal YÜCESOY², Sultan CİNGÖZ¹, M. Şerefettin CANDA¹, Metin ÇABUK¹, Safiye AKTAŞ¹

¹Departments of Pathology Dokuz Eylül University School of Medicine, Izmir, Türkiye
²Departments of Neurosurgery Dokuz Eylül University School of Medicine, Izmir, Türkiye Most adult primary brain tumors are gliomas. These tumors are progressive, tend to recur after treatment, and are usually fatal. Some studies on the behavior of astrocytomas with similar histological features have looked at over expression of p53 and c-erbB-2 and the immunoreactivity associated with this, at proliferative indices such as PCNA, and at AgNOR count. In this study, we identified a positive relationship between tumor progression and p53 and c-erbB-2 immunoreactivity. PCNA staining and AgNOR counts were higher in cases of tumor recurrence. Keywords : Astrocytomas, p53, c-erbB-2, PCNA, AgNOR

Corresponding author : Meral Koyuncuoğlu