Abstract Similar Articles

¹Department of Neurosurgery, Pamukkale University School of Medicine, Denizli
²Department of Anatomy, Hacettepe University School of Medicine, Ankara
³Department of Neurosurgery, Hacettepe University School of Medicine, Ankara The purpose of this study was to investigate the preventive effect of Ticlopidine on thrombus formation after surgical arterial injury. The model of microsurgical carotid endarterectomy was performed on the common carotid arteries in rats. Twenty rats were equally divided into two groups: a control group that received no drugs and a Ticlopidine-treated group (100 mg/kg orally 3 hours before surgery). The vessels were prepared for scanning electron microscopy and were evaluated based on the platelet aggregates at the endarterectomized site. The Mann-Whitney U test identified a statistically significant difference between the control group and the drug-treated group (U=82.50, p< 0.05). This study proves that Ticlopidine has a preventive effect on platelet aggregation in endarterectomized carotid arteries and that it can be used to reduce postoperative thrombus formation after carotid endarterectomy. Keywords : Carotid endarterectomy, microneurosurgery, postoperative thrombosis, scanning electron microscopy, thrombus formation, ticlopidine