Paraoxonase 1 Activity and Phenotype Distribution in Lumbar Disc Herniation Patients

Utku ADILAY; Nahit GENCER; Kubra CIKRIKCI; Muhammed Fatih SARI; Emad Adden ABDALLAH; Bulent GUCLU

doi:10.5137/1019-5149.JTN.44307-23.2

Issue release date: 12.11.2024

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Turkish Neurosurgery 2024 , Vol 34 , Num 4

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Paraoxonase 1 Activity and Phenotype Distribution in Lumbar Disc Herniation Patients

Utku ADILAY¹,Nahit GENCER²,Kubra CIKRIKCI²,Muhammed Fatih SARI¹,Emad Adden ABDALLAH¹,Bulent GUCLU³

¹Balikesir University, Faculty of Medicine, Department of Neurosurgery, Balikesir, Türkiye
²Balikesir University, Faculty of Science and Literature, Department of Chemistry, Balikesir, Türkiye
³Ministry of Health, Dr Lutfi Kırdar Kartal City Hospital, Neurosurgery Clinic, Istanbul, Türkiye DOI : 10.5137/1019-5149.JTN.44307-23.2 AIM: To compare the Paraoxonase 1 (PON1) activity and phenotype distribution between lumbar disc herniation (LDH) patients and healthy individuals.

MATERIAL and METHODS: This research included 40 LDH patients and 42 healthy individuals. Spectrophotometric assays were performed to determine the serum PON1 and arylesterase activities. The PON1 ratio, which represents the salt-stimulated PON/ arylesterase level, demonstrated a trimodal distribution. This ratio was applied to identify the different phenotypes; QQ, QR, and RR of each subject.

RESULTS: The LDH patients had lower PON1 activity than the healthy individuals (p<0.05). LDH patients had a statistically significant QQ phenotype compared to the healthy subjects (p<0.05).

CONCLUSION: LDH patients had statistically lower PON1 activity, suggesting that the low PON1 activity and PON1 QQ phenotype may be a risk factor for LDH occurrence. Keywords : Lumbar disc herniation, Paraoxonase, Phenotype, PON1

Corresponding author : Utku ADILAY, utkuadilay@hotmail.com