MATERIAL and METHODS: This was a retrospective, cross-sectional, single-center study with 105 consecutive patients who underwent surgery for LD. The study comprised three groups: Group I included data from healthy participants, Group II included data before LD, and Group III included data after LD. We analyzed mean platelet volume (MPV), platelet?lymphocyte ratio (PLR), neutrophil?lymphocyte ratio (NLR), SIRI, SII, MII, and PNI, in comparison with the Roland?Morris Disability Questionnaire (RMDQ), Oswestry Disability Index (ODI), and Visual analog scale for leg (VASLeg).

RESULTS: CRP and MPV were similar for the preoperative and postoperative periods (p=0.489). In the postoperative measurements, NLR, PLR, SII, and SIRI increased (p<0.0001). On the contrary, PNI decreased with LD (p<0.0001). NLR (p<0.001), SII (p<0.001), and SIRI (p<0.001) were the valuable indices for LD. PLR (p<0.001), MII-1 (p=0.004), and MII-2 (p<0.001) also predicted LD. ODI, RMDQ, and VASLeg correlated with MII-1, MII-2, and SIRI.

CONCLUSION: LD?s most substantial and valuable indices were NLR, SII, and SIRI. Regarding superiority to SII and NLR, SIRI showed significant agreement with the scales and drew a more appropriate marker profile for LD than MII-1, MII-2, and PNI. Keywords : Lumbar discectomy, Systemic immune inflammation index, Systemic inflammatory response index, Multi inflammatory index, Prognostic nutrition index