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¹KTÜ School Mediane Departments of Neurosurgery, Trabzon – Türkiye
² KTÜ School Mediane Departments of Biochemistry, Trabzon - Türkiye Five minutes before spinal cord injury, an 0.02 mg/kg dose of nimedipine was started via a femoral catheter and continued for 96 hours after injury. Pre-and post-injury and post-infusion mean arterial blood pressure (MABP) recordings were obtained. The levels of injured cord sodium-potassium-adenosine triphosphatase aetivity were measured. There was a statistically significant decrease in MABP after cord injury and also a small but not significant increase in MABP after the beginning of nimodipine infusion. The levels of injured cord Na+-K+- ATPase activity in control and nimodipine-treated groups showed no statistically significant difference (p>0.05). The results indicated that nimodipine has no effect related to the Na+-K+- ATPase activity on the cell membrane in injured spinal cord. Keywords : Experimental spinal cord, Na+-K+- ATPase, nimodipine, rat