Turkish Neurosurgery 1994 , Vol 4 , Num 1
THE EFFECT OF DEFIBROTIDE ON REENDOTHELIALISATION IN MICROARTERIAL ANASTOMOSIS
M. Memet ÖZEK1, A. Fahir ÖZER1, M. Necmettin PAMİR1, Türkan ERBENGİ2, Orhan ULUTİN3
1Marmara University School of Medicine Department of Neurosurgery, İstanbul Türkiye
2Marmara University School of Medicine Department of Histology, İstanbul Türkiye
3Marmara University School of Medicine Department of Haemostasis and Thrombosis Research Center, İstanbul Türkiye
Endothelial injury during microaterial anastomosis typically results in mural thrombus formation. However, endothelial cells produce various substances which suppress thrombus formation and maintain normal vascular wall architecture by pereventing muscular proliferation. Therefore, in order to reduce the risk of thrombus formation following microarterial anastomoses. drugs which stimulate endothelial cells and active reendothelialization might be benefictal. Using a rat model. we studied the effect of defibrtide on reendothelialization following microarterial anastomosis and concluded that defibrotide is an effective agent which supports reendothelialization and decreases the incidence of posanastomotic thrombi. Keywords : Anastomosis, Surgical, Endothelium, Microscopy, Electron, Scanning
Corresponding author : M. Memet Özek