The results showed that combined therapy with antibiotic and hyaluronidase started the day before inoculation a bacteria averted the formation of brain abscess and the same therapy started after encapsulation, effectively eliminated the organism and resolved the infection leaving a glial sear. But this therapy, only started at the cerebritis stages, caused an increase of cerebritis.

We suggest that it is possible that hyaluronidase may act in a manner similar to its local action, and additionally may activate the immune system. Therefore, the concept of management with hyaluronidase and appropriate antibiotics might be a promising and effective chemotherapeutic method in encapsulated brain abscess for selected high-risk patients. Keywords : Brain abscess, Antibiotics, Hyaluronidase, Myeobacterium bovis, Ascorbic acid