Turkish Neurosurgery 2016 , Vol 26 , Num 5
The Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas
Numan KARAARSLAN1, Mehmet Sabri GURBUZ2, Tezcan CALISKAN1, Erdogan AYAN1, Fugen VARDAR AKER3, Mehmet Zafer BERKMAN4
1Nam?k Kemal University, Faculty of Medicine, Department of Neurosurgery, Tekirda?, Turkey
2A?r? Public Hospital, Neurosurgery Clinic, A?r?, Turkey
3Haydarpa?a Numune Training and Research Hospital, Pathology Clinic, Istanbul, Turkey
4Ac?badem Hospital, Neurosurgery Clinic, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.12807-14.1 AIM: To analyse the effect of MMP-3 (Matrix Metalloproteinase Enzyme-3)-one of the extracellular matrix proteins- on the prognosis and biological behaviour of meningiomas.

MATERIAL and METHODS: 79 cases of meningioma that were operated in our clinic between 2005 and 2010 were retrospectively analysed. Age, sex, preoperative peritumoral edema, histological subtype, grade, Ki-67 expression, MMP-3 staining pattern and recurrence rate were analysed. Pathological preparations were graded according to the WHO (World Health Organisation) 2007 grading system.

RESULTS: Of the MMP-III positive cases; 24 cases (60%) were grade I, 16 cases were grade II. The MMP-3 staining pattern was significantly positive (80%) in grade II meningioma. 14 of the MMP-3 positive cases were atypical meningiomas. Of the 20 cases with high Ki-67 proliferation index (PI), 12 cases (60%) were MMP-3 positive and 8 cases (40%) were MMP-3 negative. Rates of recurrence and preoperative peritumoral edema were high in cases with MMP-3 positivity.

CONCLUSION: In this study it was determined that MMP-3 positivity has a strong relationship with meningiomas having an aggressive character. MMP-3 may be used as a proliferation marker for biological behaviour, recurrence rate and prognosis of meningiomas. Keywords : Grade, Ki-67 Proliferation index, Matrix Metalloproteinase-3, Meningioma

Corresponding author : Numan Karaarslan, numikara@yahoo.com