Issue release date: 12.11.2024
Turkish Neurosurgery
2016 , Vol 26 , Num 2
Combination of Curcumin with an Anti-Transferrin Receptor Antibody Suppressed the Growth of Malignant Gliomas In vitro
Hubei Polytechnic Institute, School of Nursing, Department of Basic Medical, Xiaogan, China
DOI :
10.5137/1019-5149.JTN.7966-13.1
AIM: Transferrin receptor (TfR) has been used as a target for the molecular cancer therapy due to its higher expression in a variety
of tumors. Anti-TfR antibodies combined with chemotherapeutic drugs has showed great potential as a possible cancer therapeutic
strategy. In our study, we investigated the anti-tumor effects of anti-TfR monoclonal antibody (mAb) alone or in combination with
curcumin in vitro.MATERIAL and METHODS: We detected the apoptosis, proliferation and cell cycle of glioma cells after treated with anti-TfR mAb and curcumin alone or the combinations by flow cytometer.
RESULTS: Anti-TfR mAb or curcumin could inhibit proliferation of tumor cells. Anti-TfR mAb marked S phase arrest and curcumin induced G2/M arrest in tumor cells. When anti-TfR mAb and curcumin were used simultaneously, a synergistic effect was detected in relation to tumor growth inhibition and the induction of cells necrosis.
CONCLUSION: These results provided a potential role of anti-TfR mAb-containing curcumin in the treatment for gliomas.
Keywords : Chemotherapeutic, Curcumin, Glioma, Transferrin receptor