Issue release date: 12.11.2024

 
Turkish Neurosurgery 1992 , Vol 2 , Num 3
EFFECTS OF DEFEROXAMINE OF LIPID PEROXIDATION IN FOCAL CEREBRAL ISCHAEMIA AND REPERFUSION (PART II)
Ö. Faruk ÜNAL, Murat DÖŞOĞLU, A. Sarper DİLER, M. Kemal HAMAMCIOĞLU, Çiçek BAYINDIR
İstanbul University, istanbul Faculty of Medicine, Departments of Neurosurgery and Physiology, İstanbul - TÜRKİYE In a reversible middle cerebral artery occlusion model in rats, the possible efficacy of deferoxamine on radical level and infarct size was investigated.

Deferoxamine was injected intravenously immediately after the occlusion at a doses of 100 mg/kg. It significantly lowered lipid peroxidation in the focal ischemic or reperfused rat brain (p<0.03), reduced the rate of infarction areas (p<0.05) and improved neurological grades (p<0.05). Keywords : Cerebral ischaemia, deferoxamine, free radicals, iron, lipid peroxidation, rat

Corresponding author : Ö. Faruk Ünal