Manic Episode Following Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson’s Disease: A Case Report

Tugce TOKER UGURLU; Goksemin ACAR; Filiz KARADAG; Feridun ACAR

doi:10.5137/1019-5149.JTN.7647-12.0

Issue release date: 12.11.2024

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Turkish Neurosurgery 2014 , Vol 24 , Num 1

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Manic Episode Following Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson’s Disease: A Case Report

Tugce TOKER UGURLU¹, Goksemin ACAR², Filiz KARADAG¹, Feridun ACAR³

¹Pamukkale University, Faculty of Medicine, Department of Psychiatry, Denizli, Turkey
²Pamukkale University, Faculty of Medicine, Department of Neurology, Denizli, Turkey
³Pamukkale University, Faculty of Medicine, Department of Neurosurgery, Denizli, Turkey DOI : 10.5137/1019-5149.JTN.7647-12.0 AIM: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for patients with Parkinson’s disease (PD) associated with motor complications of long term L-dopa treatment.

MATERIAL and METHODS: Here we report two cases with DBS- induced manic episode, focusing on the functional and anatomic correlates of psychiatric adverse effects of STN stimulation.

RESULTS: We present two cases of PD with motor complications due to long term L-dopa treatment that developed their first episodes of mania with psychotic symptoms after bilateral STN-DBS implantation. DBS-induced psychiatric adverse effects may be attributable either to limbic connections and STN-specific oscillations or stimulation of the medial forebrain bundle. Keywords : Deep brain stimulation, Subthalamic nucleus, Mania, Parkinson’s disease

Corresponding author : Tugce Toker Ugurlu, tugtoker@gmail.com