E-ISSN: 1019-5157
ISSN: 2651-5024
Case Report
Solitary Frontal Brain Metastasis From Ovarian High-Grade Serous Carcinoma With 18-Month Recurrence-Free Survival After Gross Total Resection and Multimodal Therapy: A Case Report
Nezih Oktar✉ ,
Haluk Özer ,
Eren Demirtaş ,
MAHMUT NECDET PALAZ
Neurosurgery, Ege Universitesi; Neurosurgery, BazEkol Hospital; Neuropathology, Ege Patoloji Lab
Accepted: 31/07/2026
Article in Press
Corresponding Author:
Nezih Oktar (nezih.oktar@ege.edu.tr)
Abstract
Objective:
To present a rare case of solitary frontal brain metastasis from ovarian high-grade serous carcinoma (HGSC) successfully treated with microsurgical gross total resection and multimodal oncological therapy.
Case Description:
A 44-year-old woman with platinum-sensitive ovarian HGSC developed headache, dizziness, and intermittent diplopia 2 years after initial diagnosis. MRI demonstrated a solitary 34×24×33 mm left frontal parafalcine lesion with marked edema. PET-CT showed no active systemic disease. Gross total resection was achieved using neuronavigation-guided microsurgery. Histopathology confirmed metastatic HGSC of ovarian origin (WT1+, PAX8+, CK7+, ER+, diffuse p53+, Ki-67 90%). Postoperative cavity stereotactic radiotherapy (30 Gy/5 fractions) was followed by paclitaxel-carboplatin plus bevacizumab and maintenance bevacizumab.
Conclusion:
At 18-month follow-up, the patient remains neurologically intact, seizure-free, independent, and radiologically recurrence-free (KPS 100). This case highlights that aggressive multimodal management may provide durable CNS control and excellent quality of life in selected patients with solitary ovarian brain metastasis.
To present a rare case of solitary frontal brain metastasis from ovarian high-grade serous carcinoma (HGSC) successfully treated with microsurgical gross total resection and multimodal oncological therapy.
Case Description:
A 44-year-old woman with platinum-sensitive ovarian HGSC developed headache, dizziness, and intermittent diplopia 2 years after initial diagnosis. MRI demonstrated a solitary 34×24×33 mm left frontal parafalcine lesion with marked edema. PET-CT showed no active systemic disease. Gross total resection was achieved using neuronavigation-guided microsurgery. Histopathology confirmed metastatic HGSC of ovarian origin (WT1+, PAX8+, CK7+, ER+, diffuse p53+, Ki-67 90%). Postoperative cavity stereotactic radiotherapy (30 Gy/5 fractions) was followed by paclitaxel-carboplatin plus bevacizumab and maintenance bevacizumab.
Conclusion:
At 18-month follow-up, the patient remains neurologically intact, seizure-free, independent, and radiologically recurrence-free (KPS 100). This case highlights that aggressive multimodal management may provide durable CNS control and excellent quality of life in selected patients with solitary ovarian brain metastasis.
Keywords
Ovarian carcinoma
Brain metastasis
High grade serous carcinoma
craniotomy
gross total resection
long term survival