The result of surgical therapy of sellar region neoplasms in 107 patients treated between 1986-1995 is reviewed. In this series there were 89 pituitary adenomas, 8 meningiomas, 9 craniopharyngiomas, and one mucocele. Transcranial, transphenoidal, and combined transcranial-transsphenoidal approaches were used for surgical therapy. Three patients died postoperatively. Ten patients had complications related to surgery; CSF leak in three patients, diabetes insipidus in four, meningitis in two, and abscess in one. Radiation therapy was administered to four patients postoperatively.