Amyloidosis is a progressive disorder marked by the aggregation of insoluble fibrillar proteins in various tissues, leading to tissue damage. Localised amyloidosis, known as amyloidoma, is particularly rare in the central nervous system and may be mistaken for a neoplastic lesion due to similar radiological features. Consequently, the general treatment approach often involves total excision. However, it is important to consider that a biopsy of the amyloidoma, rather than total excision, may suffice for complete recovery when paired with appropriate systemic treatment. This report presents two rare cases of amyloidoma: one located in the falx cerebri and the other in the lumbar spine. Both cases were successfully operated on, with the patients recovering without complications following treatment. (1)