Lipomas of the corpus callosum are rare congenital conditions. These lesions are often asymptomatic but may present as epilepsy, hemiplegia, dementia or headache. Computerized tomography and magnetic resonance imaging make the diagnosis of lipomas feasible at any site of the intracranial space, because of very low density attenuation values on computerized tomography and the short Tl and T2 on magnetic resonance. A direct surgical approach is very rarely necessary in these lesions. Four cases with lipoma of the corpus callosum diagnosed by computed tomography are presented and the literature is reviewed. Basic diagnostic considerations and therapeutic options are discussed.