In this study. we evaluated whether Lidocain would reduce ischaemic brain damage and restore bioelectric activity in cats subjected to permanent unilateral occlusion of the middle cerebral artery.

In the Lidocain treated group there was a statistically significant improvement in the latendes and amplitudes of somatosensory evoked potentials. The treated group showed also a more limited infarct area on the coronal brain sections. Light and electrone microscope examination revealed that the histopathological infarct process was delayed in the treated group.