E-ISSN: 1019-5157 ISSN: 2651-5024

Congress Presentations

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SEVERE PERIPHERAL NERVE INJURY DUE TO ELECTRICAL SHOCK FROM A BIPOLAR FORCEPS AS AN OCCUPATIONAL HAZARD FOR A NEUROSURGEON: A SELF EXPERIENCE

Introduction: We describe a rare instance of severe peripheral nerve injury caused by electrical shock from bipolar forceps during surgery, highlighting the challenges in treatment and recovery. This unique occupational hazard for a neurosurgeon unde...


THE EVOLUTION OF UNIVERSAL MATTER’S VIBRATIONAL PROBABILITIES MAY HAVE CREATED CONSCIOUSNESS

The evolution of matter has been progressing since the moment the universe first began to form. In the process of discovering the properties of matter, we, humanity, are increasingly able to describe the behavior of its sub-atomic particles. As long ...


Review

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Endovascular treatment versus medical management in patients with large vessel occlusion and pre-stroke disability: a systematic review and meta-analysis

Aim: Managing stroke patients with premorbid disabilities presents a challenge, as these patients are often excluded from randomized controlled trials on endovascular treatment (EVT) for large vessel occlusion (LVO). This study aimed to assess the ef...


Endoscopic-Assisted Chronic Subdural Hematoma Evacuation as an Adjunct to Middle Meningeal Artery Embolization - A Case Series and Systematic Review

Objective: Chronic subdural hematoma (cSDH) is a common neurosurgical condition in elderly patients, frequently associated with trauma, anticoagulant use, and chronic comorbidities. While surgical evacuation and now middle meningeal artery embolizati...


[alpha][alpha][alpha]Molecular And Genetic Characterization Of Atypical And Anaplastic Meningioma Implications For Prognosis And Targeted Therapy

Objectives: To characterize the molecular and genetic landscape of atypical and anaplastic meningiomas and assess their prognostic significance.\r\nMethods: This retrospective study was carried from January 2024 to January 2025. Whole-exome sequencin...


Bridging Disciplines: Collaborative Surgical Approach to Mediastinal Neurogenic Tumors

Aim: Mediastinal neurogenic tumors (MNTs) are rare neoplasms derived from neural elements within the mediastinum. While most MNTs are benign and asymptomatic, surgical resection is generally recommended due to the potential for malignant transformati...


Uric Acid in Intracranial Tumors: A Systematic Review of Diagnostic, Prognostic, and Surgical Relevance

Background and Objective:\r\nUric acid is the end product of purine catabolism and exhibits context-dependent biological effects in relation to oxidative balance and inflammation. Given the prominent metabolic and redox alterations observed in intrac...


The Effect of Surgical Timing on Outcomes in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review, Meta-Analysis, and Meta-Regression

Background: The timing of surgery for aneurysmal subarachnoid hemorrhage (aSAH) remains controversial.\r\nObjective: To evaluate the effect of earlier versus later surgery on the functional outcomes and mortality in patients with aSAH.\r\nMethods: Fo...


Prognostic Factors in Sphenoid Wing Meningiomas: Retrospective Analysis With Machine Learning and Comprehensive Literature Review in a Single Center Series.

The surgical complexity of sphenoid wing meningiomas (SWMs) leads to variable and difficult-to-predict postoperative outcomes. This study aimed to identify prognostic factors by developing a machine learning (ML) model on a single-center cohort and t...


Technical Report

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A Novel Technique to Improve Intraoperative Visualisation of the Lower Cervical Spine in Spine Surgery

Abstract\r\n\r\nStudy design: To evaluate a new technique for intraoperative visualization of the lower cervical spaces under fluoroscopy.\r\n\r\nSummary: Localizing the lower cervical spine intraoperatively using conventional fluoroscopy with latera...


Original Investigation

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Safety of Valproic Acid in Intracranial Hemorrhage: Association with Thrombocytopenia, Rebleeding, and Neurosurgical and Functional Outcomes

Valproic acid is sometimes used for seizure prophylaxis in patients with intracranial hemorrhage (ICH), but its safety in this setting, particularly regarding bleeding risk and thrombocytopenia, remains controversial.\r\nOur objective is to evaluate ...


Shennao Fuyuan Decoction Mitigates Neuronal Autophagy Following Cerebral Ischemia through Downregulation of MicroRNA-210

To explore the potential mechanism of Shennao Fuyuan Decoction underlying autophagy following cerebral ischemia.The rat model of middle cerebral artery occlusion (MCAO) was established and administrated Shennao Fuyuan Decoction intragastrically. Neur...


Putative Role of Melatonin in Neuroprotection Against Radiation-Induced Injury of the Central Nervous System

This study aims to explore the neuroprotective effects of melatonin on radiation-induced injuries in the central nervous system (CNS). The potential of melatonin to mitigate oxidative stress, a primary contributor to radiation-induced damage, is exam...


Endoscopic Transsphenoidal Surgery Outcomes in PitNETs with Suprasellar Extension: Assessment of Residual Tumor Descent into the Sella

This study evaluates the impact of suprasellar extension (SSE) morphology and radiological parameters on surgical outcomes and the descent of suprasellar residual tumors into the sella at three months postoperatively in pituitary neuroendocrine tumor...


Evaluation of Drugs with Selective Inhibitors Targeting the Anti-Apoptotic Protein B-cell Lymphoma 2 (BCL-2) with Pro-Apoptotic and Antineoplastic Activities in Grade IV Glioblastoma.

The B-cell lymphoma 2 (BCL-2) family of proteins plays a critical role in regulating apoptosis and is associated with various malignancies when dysregulated. Small-molecule inhibitors, including venetoclax (ABT-199), navitoclax (ABT-263), and obatocl...


A child wıth three legs or conjoınt parasıtıc twin?

Rachiphagus is a rare congenital anomaly where conjoined twins are fused at the vertebral column’s midline. When one of the twins is malformed, it is referred to as a parasitic twin. The term \"parasitic twin\" also encompasses cases involving extra-...


Effects of Caudal Epidural Pethidine on Pain Control and Early Mobilization after Posterior Spinal Instrumentation: A Randomized Controlled Trial

This study aimed to evaluate the effects of administering pethidine (also known as meperidine), a long-acting narcotic analgesic, via the caudal epidural route at the conclusion of posterior lumbar instrumentation (PLI) surgery on postoperative pain ...


Evaluation of The First Cervical Vertebra Anatomy for Screw Fixation

The aim of this study was to conduct a morphometrical analysis of the atlas to facilitate the development of atlas-related treatment methods and demonstrate the variations in atlas anatomy to aid surgical approaches and reduce complications.The prese...


Haemostasis versus Immunosuppression in Preventing Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats

This study compares haemostasis induced with tranexamic acid (TXA) and immunosuppression induced with infliximab (INF) as strategies to reduce epidural fibrosis (EF) in rat laminectomy model.Twenty-one male Sprague–Dawley rats were randomly assigned ...


Affordable Excellence: A Meta-Analysis on the Efficacy of Topical Tranexamic Acid in Reducing Blood Loss in Thoracolumbar Spinal Surgery

In thoracolumbar spine surgery, managing intraoperative blood loss remains a challenge. Topical tranexamic acid (tTXA) has emerged as a cost-effective alternative, providing localized antifibrinolytic effects without the systemic risks of intravenous...


Beyond Human ‘Eyes’ in Neurosurgical Exams: Success of Artificial Intelligence (ChatGPT-4o, Grok, and Gemini) in the Image-Based Questions of Turkish Neurosurgical Society Proficiency Board Exams

With the growing availability of large language models (LLMs), generative artificial intelligence has been transforming various fields. Medical training and neurosurgical education are no exception, as they are increasingly influenced by these advan...


Gamma Knife Radiosurgery for Brain Metastasis from Primary Thyroid Cancer

To analyze the efficacy and safety of Gamma Knife radiosurgery (GKRS) in the management of thyroid cancer brain metastases.This retrospective study analyzed patients who underwent GKRS for thyroid cancer brain metastases (TCBM) at two centers between...


Finite Element Analysis of Mechanical Stress Distribution in Titanium and PEEK Rod Constructs for Isthmic L5–S1 Spondylolisthesis

This study aimed to compare the biomechanical behavior of titanium and PEEK rods using finite element analysis (FEA) in a Grade I L5-S1 spondylolisthesis model.An anatomically accurate 3D finite element model of the L3–S1 spine was created from CT da...


Acute subdural hematoma: Evaluation of predictive factors and efficacy of various surgical approaches on prognosis

Acute subdural hematoma (ASH) may arise following head trauma, frequently causing death. This study examined the parameters influencing prognosis and the effectiveness of surgical techniques in patients aged over 65 years.From 2017 to 2023, a retrosp...


Comparison of the Effects of Amantadine, Methylprednisolone and Nimodipine in Sciatic Nerve Crush Injury

To assess the therapeutic effects of methylprednisolone, nimodipine, and amantadine on peripheral nerve injury using a rat sciatic nerve compression model, simulating potential treatments for humansA total of 36 adult male Wistar albino rats were div...


Investigation of the Age-Related Changes of the Atlas for Posterior Cervical Screw Fixation Surgery: A Morphometric Computed Tomography Study

The study aimed to describe the morphometry of the atlas vertebrae regarding sex and age in posterior cervical surgery, provide a data source for surgery, and compare with other populations. In surgical operations, the morphology and morphometry of t...


From Presentation to Publication: Publication Rates of Abstracts Presented at the Meetings of Two Neurosurgical Societies in Turkey

To assess the overall trends in scientific dissemination at neurosurgery meetings organized by the Turkish Neurosurgical Society (TNS) and the Society of Surgery of the Nervous System (SSNS), two major neurosurgical societies in Turkey.We reviewed 2,...


NEW ANGLE MEASUREMENT DEVICE (PROTRACTOR) FOR KYPHOSIS SURGERY TO GUIDE THE CORRECTION PROCESS: A COMPERATIVE STUDY WITH RADIOGRAPHY

The goal of spinal deformity surgery is to correct curvature in a stable and balanced way. In order to achieve this goal, radiography is used to determine the degree of angles during the operation. However, intraoperative X-ray has several disadvanta...


Brainstem Cavernoma: A Benign Lesion in A Malignant Localization

This study aims to present our surgical experience with brainstem cavernomas and to emphasize the importance of the brainstem’s internal structures. Based on the clinical data of 25 symptomatic patients who underwent surgery for brainstem cavernomas,...


A Comprehensive Assessment of Clinical, Radiological, and Histopathological Parameters in Lumbar Disc Herniation Using Correlation Matrices Analysis

To provide deeper insights into the biological mechanisms underlying disc degeneration and recurrence by studying histopathological features of excised disc tissue. Moreover, due to limited predictive role of radiological grading systems like Pfirrma...


Long-Term Outcomes of Anterior Temporal Lobectomy in Adults with Temporal Lobe Epilepsy: A Comprehensive Analysis of a 20-Year, 168-Patient Cohort

This study aims to evaluate the long-term clinical outcomes and histopathological classifications of anterior temporal lobectomy in adult patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis. Additionally, it analyzes the...


Anterior Contralateral Cervical Microdiscectomy at C7-T1

In this retrospective study, we reviewed our experience with patients who had disc herniation at C7-T1 and were treated using the senior author’s anterior contralateral simple microdiscectomy without fusion technique.From January 2000 to December 202...


Endoscopic Endonasal Approach to Identify the Medial Corridor of the Cavernous Sinus: A Cadaveric Study with Clinical Correlation

This study aimed to identify the presence and delineate anatomical boundaries of the medial corridor (MC) within the cavernous sinus (CS) using the endoscopic endonasal transsphenoidal approach. Additionally, it sought to correlate these anatomical f...


A New Measurement Technique for Lumbosacral Transitional Vertebra and Anatomic Orientation of Sacrum (Peroperative Indicator for Lumbosacral Surgery)

This study aimed to evaluate the orientation of the sacrum, its influence on sagittal balance, and its practical relevance in identifying a sacralized L5 or lumbarized S1 as an LSTV to help prevent complications.Lumbosacral vertebral roentgenograms f...


Lumbar Function and Muscle Preservation Following Hybrid Surgery Versus Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis : A Preliminary Comparative Study

Vertebral body tethering(VBT) and posterior spinal fusion (PSF) are surgical interventions used in treatment of adolescent idiopathic scoliosis(AIS). A combined approach, particularly beneficial for patients with double curves, involves PSF targeting...


Patterns of Pedicle Wall Violations Following Thoracolumbar Stabilization in Osteoporotic and Non-Osteoporotic Patients

This study aimed to investigate which pedicle level and wall were most affected by screw malpositions in osteoporotic and non-osteoporotic patients who underwent thoracolumbar stabilization, and whether there was a significant difference between the ...


Assessing the Association of Modic Changes and Clinical Outcome Before and After One-Level Lumbar Fusion

Degenerative disc disease (DDD) is a common spinal disorder associated with low-back pain (LBP) and leg pain, leading to significant disability. MRI in DDD often shows Modic changes (MCs), which are vertebral marrow alterations classified into three ...


Relationship between benign intracranial tumor location and the side of spontaneous cerebrospinal fluid leak: Insights from new cases and a systematic review

Spontaneous cerebrospinal fluid (CSF) leaks from intracranial tumors are rare, particularly before surgical excision, usually arising tumor invasion of the dura and intervening bone. Herein, we present cases of spontaneous CSF rhinorrhea and otorrhea...


Results of a Long-term Follow-up on the Dry-Field Maneuver Application in Hemorrhage Control During Neuroendoscopic Procedures

Neuroendoscopic procedures is a commonly used method today. One of the most frequent and serious complications associated with this surgery is bleeding. The dry-field maneuver is employed in cases where conventional methods such as irrigation and cau...


Mn1 Gene Overexpression In Multiple Meningioma And Comparison With Typical-Atypic Meningiomas

This study aimed to test whether MN1 expression is associated with meningioma multiplicity and to compare its distribution across typical and atypical forms. We investigate MN1 gene expression levels in multiple meningiomas and compares these levels ...


Effects of sodium nitrite on neural tube development in early-stage chick embryos

Various environmental factors, maternal supplements, and dietary additives have been associated with neural tube defects. This study aimed to investigate the effects of sodium nitrite on spinal cord development in early-stage chick embryos.Sixty spec...


Statistical Geometric Morphometric Shape Analysis of Ventricular Shape Changes in Giant Pituitary Adenomas Invading the Third Ventricle

To investigate the preoperative, early and late postoperative differences in the anterior callosal angle, lateral and third ventricle shapes of patients with pituitary macroadenoma operated via the transsphenoidal approach.: Shape data of the third a...


Pro-Con Debate for Thenar Tissue Oxygenation in Prone Position during Lumbar Discectomy

Physicians frequently use the prone position during posterior spine procedures. Microcirculation and tissue oxygenation can be impaired in this position. We aimed to compare regional tissue oxygen saturation under general, spinal, and epidural anesth...


Early and Effective Surgical Treatment of Ossified Cephalohematoma Using a Simple Technique

Cephalohematoma is an accumulation of blood in the subperiosteal space. It usually resolves spontaneously. Rarely does it not resorb, and ossification occurs. Ossified cephalic hematoma (OCH) can cause severe calvarial swelling, asymmetry, cosmetic d...


Nomogram-Based Independent Risk Factor Analysis and Recurrence Prediction for Chronic Subdural Hematoma After Single Burr Hole Drainage

Chronic subdural hematoma (CSDH) is characterized by a series of complicated neurological symptoms and usually has a good prognosis after surgical intervention, along with single burr hole drainage. However, it may recur with rates ranging from 5% to...


Optimising Spinopelvic Harmony: The Role of Strategic Transforaminal Lumbar Interbody Fusion (TLIF) and Long Fusion in Adult Degenerative Scoliosis

To evaluate the clinical and radiological outcomes after deformity correction with long-segment (>3 levels) posterior fixation and strategic TLIF in Adult Degenerative Lumbar Scoliosis and to find the correlation between clinical and radiological par...


Functional Mapping-Guided Resection of Eloquent Diffuse Low-Grade Gliomas: A Single-Institution Experience from a Low-Middle Income Country

There are logistical barriers to achieving onco-functional balance through glioma surgery in low- and middle-income countries (LMICs). We report our experience in implementing functional mapping-guided resection for eloquent diffuse low-grade gliomas...


Effect of Electrical Capacitance-Based Therapy on the Viability of U87 and T98-G Glioblastoma Cell Lines

: Glioblastoma is one of the most aggressive and lethal primary brain tumors, with survival remaining poor despite advances in multimodal therapy. In recent years, electric-field–based interventions have emerged as innovative approaches for the manag...


Surgical Management of Third Ventricular Colloid Cysts: The Fate of Open Microsurgery

To report our experience with the outcomes of open microsurgical management of third ventricular colloid cysts.This retrospective study presents the surgical outcomes of 33 patients who underwent open microsurgical resection—either through the interh...


Association of Pre-existing Comorbidities with Inpatient Outcomes in Very Elderly Patients Presenting with Primary Intracerebral Hemorrhage

Primary intracerebral hemorrhage (ICH) is known to have poor management outcomes. Very elderly patients (age > 80) might have a significantly higher incidence of worse management morbidity and mortality after primary ICH. The aim of this study was to...


Determination of Optic Nerve Sheath Diameter Cut-off after CSF Drainage in Adults with Elevated ICP: A Prospective Study

Background: Previous studies have established optic nerve sheath diameter (ONSD) cut-off values of 5.6–6.3 mm for detecting elevated intracranial pressure (ICP) (20–22 mmHg) during acute phases. However, studies on ONSD-ICP correlation post-cerebrosp...


Minimally Invasive Endoscopic Approach to Treat Large Intraventricular Tumors

To analyze the safety and effectiveness of the minimally invasive endoscopic approach (endoscope-plus-port) in the treatment of large intraventricular tumors (>5 cm). We retrospectively reviewed the demographic, radiological, and surgical data of 8 ...


EXTRAVENTRICULAR DRAIN-ASSOCIATED INFECTION RATES AND RISK FACTORS: AN 8-YEAR EXPERIENCE

Infections associated with extra-ventricular drains (EVDs) remain a major challenge in neurosurgical care. This retrospective single-center study evaluated the infection rate, causative microorganisms, resistance patterns, and clinical risk factors a...


Dose-Dependent Neuroprotection by Bevacizumab in a Hyperglycemic Trigeminal Injury Model: A Novel In Vitro Platform for Metabolic Neuropathy Research

Trigeminal neuralgia (TGN) is a disease characterized by recurrent episodes of severe pain in one or more branches of the trigeminal nerve, and the effectiveness of current treatments is limited, especially in patients with metabolic disorders. This ...


Impact of DNA methylation profiling on central nervous system tumor diagnosis and management: A pediatric cohort study from Türkiye

DNA methylation–based tumor classification (MBTC) has emerged as a valuable adjunct for diagnostically challenging central nervous system (CNS) tumors. MBTC is routinely applied at Acibadem University to pediatric cases with indeterminate morphology ...


De novo Vessels and Blood–Brain Barrier-like Structures in Inner Membranes of Chronic Subdural Hematomas: First Report of Histopathological Basis of Recurrence and Enlargement

Chronic subdural hematoma (CSDH) is an encapsulated collection of blood at different stages of coagulation that accumulates at the dural border cell layer. However, the mechanisms underlying the development of de novo vessels in the inner membranes a...


Validation of a 3D-Printed Facet Injection Training Model with Real-Time Feedback: A Prospective Study on Neurosurgical Residents

Pain injections are one of the most commonly done spinal procedures, yet there are no structured and safe platforms for teaching. We aimed to create a low-cost, 3D-printed lumbosacral model with real-time feedback for training residents in lumbar fac...


ANATOMICAL FRAMEWORK OF THE ENDOSCOPIC TRANSSPHENOIDAL APPROACH TO THE THIRD VENTRICLE

Surgical access to the third ventricle is particularly challenging because of its deep location and close relationship with critical neurovascular structures. The endoscopic transsphenoidal (ETS) approach provides access deeply situated structures su...


Brain Metastases in Pediatric Extracranial Solid Tumors: A 20-Year Experience in Challenging a Rare Diagnosis

This study investigates the clinical features, treatments, and outcomes of pediatric patients with brain metastasis from extracranial solid tumors, a rare condition.Over a 20-year period, 520 children treated for extracranial solid tumors in our radi...


Surgical Management of Rhinorrhea: Is It Appropriate to Compare Transsphenoidal and Transcranial Approaches? A Single-Center Long-Term Experience

Anterior skull base cerebrospinal fluid (CSF) fistulas may result in persistent rhinorrhea with a risk of serious infections such as meningitis. In this study, we reviewed our institutional experience and surgical outcomes in patients who underwent r...


A Retrospective Study of Tranexamic Acid Improving Visual Field Clarity in Unilateral Biportal Endoscopic Spine Surgery

To evaluate whether intravenous tranexamic acid (TXA) before unilateral biportal endoscopic spine surgery (UBE) can improve the visual field clarity, reduce postoperative pain and recovery quality.Analysis of the visual clarity, blood loss, and posto...


Complications of Biportal Endoscopic Surgery for Lumbar Pathologies: A Retrospective Analysis of 374 Cases

This study aims to evaluate the complications associated with Unilateral Biportal Endoscopy (UBE) in spinal surgery, highlighting the risks and outcomes of this minimally invasive approach.A retrospective analysis was conducted on 374 patients who un...


Predicting Postoperative Rebleeding After Emergency Craniotomy in TBI: Development and Validation of a Comprehensive Nomogram

Postoperative bleeding after emergency craniotomy for traumatic brain injury (TBI) continues to be a leading cause of death and long-term disability. Current predictive models of risk factors are based on a very limited number of variables or only co...


Delayed Cerebral Ischemia after Subarachnoid Hemorrhage: The Role of Surgical Timing and Inflammatory–Metabolic Markers

Delayed cerebral ischemia (DCI) influences poor outcome after subarachnoid hemorrhage (SAH). We evaluated the prognostic value of clinical variables, inflammatory and metabolic markers, and surgical timing for DCI in aneurysmal and nonaneurysmal SAH....


C2 Vertebral Morphometry and Feasibility of Conventional C2 Instrumentation in Patients with Chiari I Malformation

To investigate C2 morphometry, prevalence of high-riding vertebral artery (HRVA) and feasibility of conventional C2 screw instrumentation for Chiari malformation type I (CM-I) patients without basilar invagination, and to compare these parameters wit...


Comparison of Polymorphisms in Genes Encoding Serum Matrix Metalloproteinase-1 and -12 between Patients with Invasive Pituitary Macroadenomas and Healthy Individuals

Pituitary adenomas may present invasive features, accounting for a considerable number of intracranial malignancies. Matrix metalloproteinases (MMPs) are endopeptidases that play key roles in extracellular matrix remodeling, tumor invasion, and metas...


Shape Analysis of the Corpus Callosum in Pediatric Hydrocephalus: A Comparison Between Cases With and Without Shunt Revision Surgery

This study aimed to investigate corpus callosum shape differences in pediatric hydrocephalus patients with and without shunt revisions.Midsagittal magnetic resonance imaging images from 45 cases (25 with and 20 without shunt revision surgeries) that ...


Heart-Shaped Suturing to Improve Scar Formation in Pediatric Tethered Cord Syndrome Surgery

To evaluate the clinical efficacy of heart-shaped suturing in improving postoperative scar formation in pediatric patients undergoing tethered cord syndrome (TCS) surgery.Seventy-two pediatric patients diagnosed with TCS between April and December 20...


Dysraphic Tethering Syringomyelia in Split Cord Malformation: Proposal of a Novel Terminology—Rostral Junctional Segmental Syringomyelia

This retrospective study aimed to investigate the radiological and clinical features of syringomyelia in patients with spinal dysraphism accompanied by split cord malformation (SCM). A secondary objective was to propose a specific terminology to desc...


Predictive Value of Cerebrospinal Fluid Hydrodynamic Parameters for Short-term Postoperative Outcomes in Patients with Syringomyelia

To evaluate the predictive value of cerebrospinal fluid (CSF) hydrodynamic parameters for short-term postoperative outcomes in patients with syringomyelia (SM).200 SM patients, including both Chiari I malformation–related and non-Chiari cases, treate...


A comparative study of large language models in Turkish neurosurgery education using a mock neurosurgery board examination

Large language models (LLMs) are being used more often in medicine, but their impact on neurosurgical education is not well studied. To our knowledge, this study is the first to evaluate Deepseek-R1, Gemini-2.0 Pro, ChatGPT-o3-mini-high, and GPT-4.5 ...


Unilateral Biportal Endoscopy for Lumbar Disc Herniation and Spinal Stenosis: Clinical Outcomes and Complication Analysis

Degenerative spinal diseases including lumbar disc herniation (LDH) and lumbar spinal stenosis (LSS) are well-known factors which significantly impair quality of life. Unilateral biportal endoscopic (UBE) technique is an innovative minimally invasive...


Surgical Treatments of C1 Fracture: Can Preoperative Dynamic Tomography Improve Surgical Outcomes?

To investigate whether preoperative dynamic computed tomography improves\r\nsurgical decision-making and radiological and clinical outcomes in patients with\r\nunstable fractures of the atlas vertebra.A retrospective review was performed of patients ...


The Impact of Extended Adjuvant Temozolomide Beyond the Standard Six Cycles in Newly Diagnosed Glioblastoma

The results regarding the use of more than six courses of adjuvant temozolomide (TMZ) in glioblastoma remain controversial. In the current study, we focused on comparing the survival outcomes of patients treated with the standard six courses of adjuv...


Ferulic Acid Increases Temozolomide Sensitivity in Glioblastoma Cells, Causing Dna Damage and Inhibiting Cell Proliferation

Glioblastoma Multiforme (GBM) is an aggressive brain tumor with a poor prognosis, characterized by resistance to chemotherapy and high invasiveness. Although temozolomide (TMZ) is used as a standard chemotherapeutic agent in GBM treatment, the limite...


CORRECTION MANEUVERS USING SEQUENTIAL TEMPORARY SHORT ROD DISTRACTION TECHNIQUE IN SEVERE NEUROMUSCULAR SCOLIOSIS: RETROSPECTIVE STUDY AND TECHNICAL NOTE

The aim of this study was to describe a surgical technique that enables maximal and safe correction while minimizing complication rates in patients with severe neuromuscular scoliosis.We retrospectively reviewed patients with neuromuscular scoliosis ...


Intraoperative Neuromonitoring in Turkey: A National Survey of Neurosurgeons’ Practices and Attitudes

Intraoperative neuromonitoring (IONM) is increasingly used in neurosurgical practice, yet its implementation and training background remain heterogeneous. This study aimed to provide an overview of current IONM practices and attitudes among neurosurg...


Optic Nerve Sheath Diameter in Infantile Hydrocephalus Follow-Up: Clinical Insights from CT-Based Measurements

This study evaluated changes in optic nerve sheath diameter (ONSD) values measured by computed tomography (CT) in infants who had undergone surgery for hydrocephalus and assessed their correlation with the Evans index (EI).Between January 2016 and De...


The value of indocyanine green video angiography in surgery of anterior circulation cerebral aneurysms

Intraoperative assessment is critical in cerebral aneurysm surgery to ensure complete occlusion while preserving adjacent vessels. While digital subtraction angiography (DSA) remains the gold standard, indocyanine green video angiography (ICG-VA) off...


Etiology, Long-Term Outcomes, and Prognostic Factors in Children with Refractory Epilepsy Undergoing Epilepsy Surgery

To investigate the etiological spectrum, presurgical characteristics, and long-term surgical outcomes in children with drug-resistant epilepsy (DRE) and to identify clinical, electrophysiological, and imaging-based predictors of favorable outcomes.A ...


Evaluation of Microsatellite Instability in Chordomas

Chordomas (CH) are malignant bone neoplasms with notochordial origin accepted to arise from the notochord reminants. Their response to chemotherapy is poor and this is an important limitation for treatment. Microsatellite instability (MSI) screening ...


Downregulation of miR-221, miR-143 and miR-22 in meningioma and their diagnostic performance: a single-center case–control study

Tissue microRNAs (miRNAs) are implicated in meningioma biology, yet practical diagnostic markers remain limited. We evaluated four candidates—miR-221, miR-143, miR-22 and miR-145—in an expanded single-center cohort to define expression patterns and d...


Comparison of Gamma Knife and LINAC-Based Radiosurgical Techniques for Malignant Brain Tumors: Evaluation of Dosimetric Parameters and Treatment Efficacy

This study aims to compare Gamma Knife (GK) and Linac-based stereotactic radiosurgery (SRS) techniques for malignant brain tumors with increasing tumor volumes, focusing on Conformity Index (CI), Paddick Conformity Index (PCI), Homogeneity Index (HI)...


A Bibliometric Analysis of 500 Articles on the Use of Artificial Intelligence in Neurosurgery

The aim of this bibliometric analysis was to systematically map and quantitatively evaluate the global scientific literature on artificial intelligence applications in neurosurgery.The Web of Science (WoS) Core Collection database was searched on Oct...


Vigabatrin Mitigates Secondary Injury in Traumatic Spinal Cord Injury via Potent Inhibition of Ferroptosis: A Novel Neuroprotective Mechanism

Traumatic spinal cord injury (TSCI) involves secondary injury via apoptosis, inflammation, oxidative stress, and ferroptosis. This study investigated the neuroprotective effects of Vigabatrin, a GABA-transaminase inhibitor, in a rat TSCI model, focus...


Outsmarting the Troublemaker: A Subpectoral Protocol for Implantable Pulse Generators

Hardware-related complications remain a notable concern in deep brain stimulation (DBS) surgeries; infections and erosions account for approximately 5%, with implantable pulse generator (IPG)-related problems accounting for a substantial proportion.....


En-Bloc And Central Bone Strip Preservation Bifrontal Decompressive Craniectomy For Traumatic Bifrontal Contusion : A Comparative Analysis Of Surgical Safety And Clinical Outcome

En-bloc and central bone strip–sparing techniques are two approaches for bifrontal decompressive craniectomy (DC), commonly performed in patients with traumatic bifrontal contusions. While en-bloc DC is more widely practiced, central bone strip prese...


Analysis of Genomes and Transcriptomes of glioma Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor beta Pathway

Glioblastoma (GBM) is the most aggressive malignant brain tumor in adults, with poor prognosis despite current standard treatments. While immune checkpoint inhibitors (ICIs) such as PD-1 blockade have shown promise in several cancers, their efficacy ...


Surgical Treatment Outcome Prediction Score for Traumatic Brain Injury

The postoperative prognosis after decompression surgery for traumatic brain injury (TBI) remains poor, with some patients left in a vegetative state or dying postoperatively. This study aimed to develop a simple preoperative scoring system to predict...


Radiographic evaluation of vidian nerve protrusion and its association with volume of sphenoid sinus in a subset of Pakistani population

This study aimed to analyze the association between sphenoid sinus volume (Sv) and vidian nerve (VN) protrusion using computed tomography (CT) images.This prospective cross-sectional study was conducted in the radiology department of a tertiary care ...


Comparative Analysis of Stereotactic Radiosurgery Modalities in Brain Metastases

This study aims to compare the dosimetric performance and QA outcomes of CyberKnife, Radixact, and Linac-based VMAT (Monaco and RayStation TPS) for brain metastases, providing evidence-based guidance for modality selection based on tumor characterist...


In-vitro Investigation and the Effect of Endoscopes on Spinal Epidural Pressure Changes with a Dynamic Irrigation Pump

Full-endoscopic spinal surgery has been associated with several unique complications that may be related to increased epidural pressure. Reported complications include headache, neck pain, seizures, and intracranial or retinal hemorrhage. This study ...


Can Artificial Intelligence Evaluate Clinical Practice Guidelines Like Human Experts? A Comparative Study Using the AGREE II Instrument

Clinical practice guidelines (CPGs) are widely used in neurosurgery to support evidence-based clinical decisions and to promote consistency in patient management. However, their methodological quality and internal consistency vary substantially acros...


Case Report

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Ruptured Vertebral Artery Aneurysm in a Patient with Loeys-Dietz Syndrome Type 4, A Sentinel Case Report

Loeys-Dietz Syndrome (LDS) is a rare, autosomal dominant connective tissue disorder with an estimated prevalence of less than 1 in 100,000. LDS results from one of several genetic mutations altering the transforming growth factor β (TGF- β...


Emergent endovascular parent artery occlusion for type 3 carotid blowout syndrome after charged particle therapy for recurrent maxillary carcinoma: a case report and literature review.

A 55 year old woman presented to the emergency room in shock state, bleeding from the oral and nasal cavity. The patient was a known case of recurrent maxillary carcinoma performed radiation therapy 9 years ago. Digital subtraction angiography reveal...


Intracranial Mature Bone Formation: Report of Three Uncommon Cases and a Proposed Pathogenetic Mechanism

Abstract \r\nThe formation of histologically mature bone within the intracranial compartment is an exceptionally rare phenomenon. Although intracranial calcifications are frequently encountered in clinical practice, true ossification culminating in t...


Posterolateral Approach for Recurrent multi-level Ventral Intradural Extramedullary Cervical Spinal Meningioma

Spinal meningiomas are common intradural spinal tumors. Recurrent multilevel ventral intradural extramedullary spinal meningiomas, especially those presenting several years post-initial surgery is rare and can be particularly challenging to treat. We...


Takayasu arteritis complicated with vertebral artery dissection aneurysm treated endovascularly:report of one case

Takayasu arteritis is a chronic granulomatous large-vessel vasculitis primarily affecting the aorta and its major branches such as the subclavian, carotid, and renal arteries. Pathologically, it is characterized by transmural infiltration of lymphocy...


Pre-therapeutic Vascular Anatomical Evaluation in Penetrating Cerebrovascular Injuries: Insights from Two Cases

Penetrating cerebrovascular injuries (PCVIs) are often life-threatening, with trauma to the carotid or vertebral arteries potentially causing severe neurological deficits. This study aimed to retrospectively examine two cases of severe penetrating ce...


Accessory Nerve Meningioma of the Foramen Magnum: A Rare Neurosurgical Entity

Background:\r\nMeningiomas, which are the most common primary intracranial tumors, frequently arise from the dura of the convexities, parasagittal regions, and skull base. The accessory nerve (cranial nerve XI) at the level of the foramen magnum is a...


Recurrent and De Novo Internal Carotid Artery Aneurysms with Severe Stenosis Following Radiation Therapy for Nasopharyngeal Carcinoma: A Rare Case Report

Rapid formation and recurrence of aneurysms accompanied by severe arterial stenosis following radiation therapy (RT) for nasopharyngeal carcinoma (NPC) is an uncommon clinical phenomenon. We present the case of a 51-year-old man who developed subarac...


Advanced detection of a small intracranial aneurysm using photon-counting computed tomography angiography

Aim:\r\nThis technical report illustrates the potential of photon-counting computed tomography angiography (PCCT-A) in detecting small, incidental intracranial aneurysms, which are often missed by conventional imaging.\r\n\r\nMaterial and Methods:\r\...


Intracranial Neuroenteric Cyst in the Cerebellopontine Angle with Calcified Cyst Wall: A Rare Case Report

Background: Neuroenteric cysts (NCs) are rare benign lesions believed to originate from ectopic endodermal tissue. They are lined by gastrointestinal or respiratory epithelium capable of secreting mucin. Although most frequently located within the sp...


AN UNUSUAL COMPLICATION AFTER POSTERIOR THORACOLUMBAR STABILIZATION SURGERY, RENAL HERNIA: A CASE REPORT

Grynfeltt–Lesshaft hernia is a rare type of posterolateral abdominal wall hernia that may be either congenital or acquired. Only a few cases have been reported following surgical procedures. The risk of herniation increases after surgeries involving ...


Gamma Knife Radiosurgery–Induced Acute Facial Palsy in Vestibular Schwannoma: A Case Report

Stereotactic radiosurgery (SRS) is an established treatment for vestibular schwannoma, offering high tumor control rates and a favorable safety profile. SRS-induced facial palsy is typically a late-onset complication, with acute-onset cases being exc...


Coexistence of Chiari 1 Malformation and Marsh 3b Celiac Disease: First Reported Case

This case report presents the first simultaneous occurrence of Chiari malformation type 1 and celiac disease in a 27-year-old male patient; to the best of our knowledge, there are no previously published cases in the literature. This rare association...


The First Reported Case of a Hemorrhagic Solitary Fibrous Tumor at the Cerebellopontine Angle Successfully Managed with Multimodal Therapy

Introduction: Intracranial solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms, and cases of tumor bleeding are rarely seen. While radiographically similar to meningioma, SFTs exhibit a more aggressive clinical course. Surgical resection fo...


Challenges of Complex AVM Resection in Regional and Community Hospitals: A Case Report

We report the microsurgical management of a complex diffuse arteriovenous malformation (AVM) in a regional hospital. A 46-year-old woman with hypertension and chronic kidney disease presented with a five-day history of mood changes, emotional labilit...


Combined Transdural and Transpedicular Surgical Approach for Giant Calcified Thoracic Disc Herniation: A Case Report

Calcified thoracic disc herniations (CTDH) are a rare spinal pathology that can cause progressive myelopathy and presents formidable surgical challenges due to their adherence to surrounding tissues. Herein, we describe the staged surgical management...


GPI Targeting for Holmes Tremor due to Hemorrhagic Cavernoma Located in the Subtalamic Nucleus

Objective: We describe a rare case of Holmes tremor (HT) secondary to a hemorrhagic cavernoma and assess the effectiveness of deep brain stimulation (DBS), specifically targeting the globus pallidus internus (GPI), in the presence of coexisting dysto...


MPO - ANCA - Related Thoracic Spinal Hypertrophic Pachymeningitis: A Case Report

Background:\r\nHypertrophic spinal pachymeningitis (HSP) is a rare inflammatory disorder characterized by progressive thickening of the spinal dura mater. The diagnosis requires careful exclusion of infectious, autoimmune, and neoplastic etiologies. ...


Malignant Melanoma and Intratumoral Hemorrhage in a Patient with LEOPARD Syndrome: A Rare Case Report

Background\r\nLEOPARD syndrome is a rare autosomal dominant disorder characterized by multiple lentigines, hypertrophic cardiomyopathy, conduction abnormalities, and variable systemic features. Malignancies are uncommon but have been reported in affe...


Title: Surgical Management of Geniculate Neuralgia: The Necessity of Nervus Intermedius Sectioning and Multi-Cranial Nerve Assessment

AIM: Geniculate neuralgia (GN) is a rare craniofacial pain syndrome characterized by severe lancinating pain in the ear.1 Its diagnosis is complex due to the sensory overlap of cranial nerves (CN) V, VII, IX, and X. We present two cases of GN treated...


Langerhans Cell Histiocytosis with Cervical Spine Involvement: A Rare Case and Review of the Literature

Introduction:\r\nLangerhans cell histiocytosis is a rare systemic disorder, and spinal involvement is exceptionally uncommon. This study aims to report a rare case of Langerhans cell histiocytosis affecting the cervical spine and to discuss the condi...


L4 Transpedicular Nerve Root Anomaly: The First Non-Syndromic Case Report

Anatomical variations of lumbar nerve roots are rare, and transpedicular root courses are extremely uncommon. We present the first nonsyndromic and incidentally detected case of an L4 transpedicular nerve root anomaly. A 45-year-old woman presented w...


Giant Multiple Cerebral Hydatid Cysts Causing Herniation: A Case Report

Hydatid cyst disease is a zoonotic infection caused by the parasite Echinococcus granulosus that typically affects the liver and lungs, whereas cerebral involvement is uncommon. This case report describes multiple cerebral hydatid cysts (approximatel...


Pituitary Metastasis of Cervical Squamous Cell Carcinoma

Abstract\r\nObjective: Pituitary metastases are rare, constituting only 1-2% of sellar masses. While various malignancies can metastasize to the pituitary gland, cervical cancer with isolated pituitary involvement is exceptionally uncommon. Literatur...


Primary Schwannoma of the Olfactory Groove: A Rare Extra-Axial Tumour Mimicking Meningioma.

Schwannomas originate from Schwann cells, have a benign character and are classified as nerve sheath tumours. These tumours can occur anywhere within the nervous system that contains Schwann cells. Intracranially, they are most commonly found in the ...


A Diagnostic Pitfall in Lumbar Radiculopathy: Isolated Lumbar Myeloid Sarcoma Initially Interpreted as Disc Herniation

Myeloid sarcoma (MS) is a rare extramedullary malignant tumor composed of immature myeloid precursor cells, most commonly associated with hematologic disorders, such as acute myeloid leukemia, but occasionally presenting as an isolated lesion without...


In Memoriam

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In Memory of Dr. Zeki Oral

In Memory of Dr. Zeki Oral\r\n\r\nDr. Zeki Oral was born in Anamur in 1940. He completed his primary and secondary education in Anamur and his high school education in Bursa. In 1966, he graduated from Istanbul Faculty of Medicine and, in the same ye...


Gazi Yaşargil Was Not Only a Neurosurgeon but Also a Neuroartist

Professor M. Gazi Yaşargil (1925–2025), celebrated worldwide as the “Neurosurgeon of the Century,” revolutionized neurosurgery through his pioneering introduction of the surgical microscope, the development of microsurgical instruments, and the creat...