E-ISSN: 1019-5157 ISSN: 2651-5024

Original Investigation

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Impact of DNA Methylation Profiling on Central Nervous System Tumor Diagnosis and Management: A Pediatric Cohort Study from Türkiye
[Abstract] [Similar Articles]

AIM: To present a single-center experience, and to highlight the urgent need for multi-institutional collaboration in Türkiye and surrounding regions lacking access to methylation platforms, with the aim of enhancing diagnostic precision and neuropathological practice. MATERIAL and METHODS: All p...


Transnasal Transsphenoidal versus Transcranial Surgery for Resection of Sellar Lesions; A National Database Analysis
[Abstract] [Similar Articles]

AIM: To present a national database analysis comparing transnasal transsphenoidal (TNTS) and transcranial (TC) approaches in sellar lesion management. MATERIAL and METHODS: We analyzed the National Surgical Quality Improvement Program (NSQIP) database by TNTS and TC CPT codes from 2014-2018. Outc...


Shape Analysis of the Corpus Callosum in Pediatric Hydrocephalus: A Comparison Between Cases with and without Shunt Revision Surgery
[Abstract] [Similar Articles]

AIM: To investigate corpus callosum shape differences in pediatric hydrocephalus patients with and without shunt revisions. MATERIAL and METHODS: Midsagittal magnetic resonance imaging studies from 45 cases (25 with and 20 without shunt revision surgeries) that underwent ventriculoperitoneal shunt...


Acute Subdural Hematoma: Evaluation of Predictive Factors and Efficacy of Various Surgical Approaches on Prognosis
[Abstract] [Similar Articles]

AIM: To examine the parameters influencing prognosis, and the effectiveness of surgical techniques in patients aged over 65 years with acute subdural hematoma (ASH). MATERIAL and METHODS: From 2017 to 2023, a retrospective evaluation was conducted on 62 individuals admitted to the emergency depar...


A Comparative Study of Large Language Models in Turkish Neurosurgery Education Using a Mock Neurosurgery Board Examination
[Abstract] [Similar Articles]

AIM: To evaluate Deepseek-R1, Gemini-2.0 Pro, ChatGPT-o3-mini-high, and GPT-4.5 on a mock neurosurgery board exam to assess their accuracy and educational value. MATERIAL and METHODS: We created a 50-question mock neurosurgery board examination and administered it to three major large language mo...


Evaluation of the First Cervical Vertebra Anatomy for Screw Fixation
[Abstract] [Similar Articles]

AIM: To conduct a morphometrical analysis of the atlas to facilitate the development of atlas-related treatment methods and demonstrate the variations in atlas anatomy to aid surgical approaches and reduce complications. MATERIAL and METHODS: The present study was conducted on 58 dry human atlas v...


Comparison of the Effects of Amantadine, Methylprednisolone and Nimodipine in Sciatic Nerve Crush Injury
[Abstract] [Similar Articles]

AIM: To assess the therapeutic effects of methylprednisolone, nimodipine, and amantadine on peripheral nerve injury using a rat sciatic nerve compression model, simulating potential treatments for humans. MATERIAL and METHODS: A total of 36 adult male Wistar albino rats were divided into five groups...


Effects of Caudal Epidural Pethidine on Pain Control and Early Mobilization after Posterior Spinal Instrumentation: A Randomized Controlled Trial
[Abstract] [Similar Articles]

AIM: To evaluate the effects of administering pethidine (also known as meperidine), a long-acting narcotic analgesic, via the caudal epidural route at the conclusion of posterior lumbar instrumentation (PLI) surgery on postoperative pain control, and early mobilization of patients. MATERIAL and M...


Finite Element Analysis of Mechanical Stress Distribution in Titanium and PEEK Rod Constructs for Isthmic L5-S1 Spondylolisthesis
[Abstract] [Similar Articles]

AIM: To compare the biomechanical behavior of titanium and polyetheretherketone (PEEK) rods using finite element analysis (FEA) in a Grade I L5-S1 isthmic spondylolisthesis model. MATERIAL and METHODS: An anatomically accurate 3D finite element model of the L3?S1 spine was created from CT data of ...


Complications of Biportal Endoscopic Surgery for Lumbar Pathologies: Retrospective Analysis of 374 Cases
[Abstract] [Similar Articles]

AIM: To evaluate the complications associated with Unilateral Biportal Endoscopy (UBE) in spinal surgery, highlighting the risks and outcomes of this minimally invasive approach. MATERIAL and METHODS: A retrospective analysis was conducted on 374 patients who underwent UBE at three centers from 2...


Hemostasis Versus Immunosuppression in Preventing Postlaminectomy Epidural Fibrosis: An Experimental Study in Rats
[Abstract] [Similar Articles]

AIM: To compare haemostasis induced with tranexamic acid (TXA) and immunosuppression induced with infliximab (INF) as strategies to reduce epidural fibrosis (EF) in rat laminectomy model. MATERIAL and METHODS: Twenty-one male Sprague?Dawley rats were randomly assigned into control group (no treatm...


Affordable Excellence: A Meta-Analysis on the Efficacy of Topical Tranexamic Acid in Reducing Blood Loss in Thoracolumbar Spinal Surgery
[Abstract] [Similar Articles]

AIM: To evaluate the efficacy and safety of topical tranexamic acid (tTXA) in thoracolumbar fusion surgery. MATERIAL and METHODS: A systematic review was conducted per PRISMA guidelines. Studies from January 1970 to August 2024 were retrieved from PubMed, Cochrane, EMBASE, Medline, and Google Scho...


From Presentation to Publication: Publication Rates of Abstracts Presented at the Meetings of Two Neurosurgical Societies in Türkiye
[Abstract] [Similar Articles]

AIM: To assess the overall trends in scientific dissemination at neurosurgery meetings organized by the Turkish Neurosurgical Society (TNS) and the Society of Surgery of the Nervous System (SSNS), two major neurosurgical societies in Turkey. MATERIAL and METHODS: We reviewed 2,696 abstracts presen...


Beyond Human 'Eyes' in Neurosurgical Exams: Success of Artificial Intelligence (ChatGPT-4o, Grok, and Gemini) in the Image-Based Questions of Turkish Neurosurgical Society Proficiency Board Exams
[Abstract] [Similar Articles]

AIM: To evaluate the impact of generative artificial intelligence and large language models (LLMs) on medical training and neurosurgical education, specifically focusing on their emerging capabilities in image interpretation. MATERIAL and METHODS: This study evaluated the performance of three majo...


Case Report

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Emergent Endovascular Parent Artery Occlusion for Type III Carotid Blowout Syndrome After Charged Particle Therapy for Recurrent Maxillary Carcinoma: A Case Report and Literature Review
[Abstract] [Similar Articles]

Carotid blowout syndrome (CBS) refers to involvement of the carotid artery by malignant processes of the head and neck with compromise of vessel integrity and rupture. Carotid hemorrhage (CBS type III) is fatal, particularly when it occurs outside hospital settings. Bleeding can occur through the ...


Intracranial Mature Bone Formation: Report of Three Uncommon Cases and a Proposed Pathogenetic Mechanism
[Abstract] [Similar Articles]

The formation of histologically mature bone within the intracranial compartment is an exceptionally rare phenomenon. Although intracranial calcifications are frequently encountered in clinical practice, true ossification culminating in the development of mature bone tissue remains poorly character...


Posterolateral Approach for Recurrent Multi-Level Ventral Intradural Extramedullary Cervical Spinal Meningioma
[Abstract] [Similar Articles]

Spinal meningiomas are common intradural spinal tumors. Recurrent multilevel ventral intradural extramedullary spinal meningiomas, especially those presenting several years post-initial surgery is rare and can be particularly challenging to treat. We report two cases of such recurrent multilevel v...


Systematic Review

(1)
Evaluation of Drugs with Selective Inhibitors Targeting the Anti-Apoptotic Protein B-cell Lymphoma 2 (BCL-2) with Pro-Apoptotic and Antineoplastic Activities in Grade IV Glioblastoma
[Abstract] [Similar Articles]

AIM: To systemically review the efficacy, safety, and clinical applications of B-cell lymphoma 2 (BCL-2) family inhibitors such as venetoclax (ABT-199), navitoclax (ABT-263), and obatoclax (GX15-070) across different malignancies. MATERIAL and METHODS: A systematic search was conducted in the PubM...