Turkish Neurosurgery 2010 , Vol 20 , Num 2
Efficacy of Clinical Prognostic Factors on Survival in Patients with Glioblastoma
Bekir TUGCU, Lutfi Sinasi POSTALCI, Omur GUNALDI, Osman TANRIVERDI, Hidayet AKDEMIR
Bakřrk÷y Research and Training Hospital for Neurology, Neurosurgery and Psychiatry, 2nd Neurosurgery Clinic, Ţstanbul, Turkey DOI : 10.5137/1019-5149.JTN.2461-09.4 AIM: Glioblastoma is the most common and highest-grade infiltrative astrocytoma. It is usually associated with a bad prognosis. Histological grading is highly predictive of an aggressive behavior, with a mean survival rate of 1 year. Nonetheless, individual patient survival can vary substantially, ranging from 1 month to over 5 years. Several distinct clinical parameters and molecular alterations have recently been described in glioblastoma. The present study compares clinical, radiologic and therapeutic parameters in a series of glioblastomas to identify prognostic factors.

MATERIAL and METHODS: We evaluated 50 cases who were operated on for intracranial glioblastoma between January 1998-March 2004 retrospectively. All clinical records, radiological records and management modalities were evaluated as prognostic value.

RESULTS: The mean survival time was 7.5 months (range, 1-18 months). We confirmed the patients' age, gender, Karnofsky Performance Scale score at discharge, postoperative radiotherapy and reoperation as decisive prognostic factors after multivariate analyses.

CONCLUSION: We could show that some clinical parameters and treatment modalities were associated with prognosis. Younger age, male gender, higher Karnofsky Performance Score at discharge, total surgical resection, radiotherapy and reoperation were predictor for better prognosis. Keywords : Glioblastoma, Survival time, Prognosis

Corresponding author : Bekir Tugcu, bekirtugcu@superonline.com