Turkish Neurosurgery 1996 , Vol 6 , Num 1-2
THERAPEUTIC TRIAL OF NIMODIPINE IN GOOD CONDITION SAH PATIENTS' WITH ANEURYSMS AT THE SAME LOCATION
E. Metin GNER, mit D. ACAR, Serhat ERBAYRAKTAR
University of Dokuz Eyll, School of Medicine, Department of Neurosurgery Izmir, Trkiye Since 1993, we have been using nimodipine in patients admitted to hospital before the fifth day of their initial subarachnoid haemorrhage. During this period, 84 patients were treated surgically and among them, 34 were admitted to our study of nimodipine groups. We have tried lo investigate the benefits of nimodipine when added lo routine medical therapy against vasospasm, in patients whose preoperative and peroperative conditions were similar, and aneurysms were at the same location. For this purpose, we constructed nimodipine and control groups for anterior communicating artery, internal carotid artery, and middle cerebral artery aneurysms. Patients chosen for the control groups, had been treated before 1993 with the same approach, but without nimodipine. We analysed early postoperative grades, angiographic and computerized tomographic appearances, and outcomes at the third postoperative month. In anterior communicating artery aneurysm patients, there were significant differences between nimodipine and control groups for these parameters, but the outcome (p<0.05). Inversely, there was no significant difference in internal carotid and middle cerebral mtery aneurysm patients for any of the parameters. Keywords : Cerebral aneurysm, intravascular volume expansion, ischaemia, nimodipine, subarachnoid haemorrhage
Corresponding author : E. Metin Gner