Turkish Neurosurgery 2017 , Vol 27 , Num 6
Effects of Topical CovaTM, Tisseel« and Adcon«Gel Application on the Development of Spinal Peridural Fibrosis: An Experimental Study in Rats
Atilla KAZANCI1,Oktay GURCAN1,Ahmet Gurhan GURCAY1,Evrim ONDER2, Burak KAZANCI3,Mesut Emre YAMAN4,Murad BAVBEK1
1Ataturk Research and Education Hospital, Department of Neurosurgery, Ankara, Turkey
2Diskapi Yildirim Beyazit Training and Research Hospital, Department of Pathology, Ankara, Turkey
3Ufuk University, Department of Neurosurgery, Ankara, Turkey
4Memorial Hospital, Department of Neurosurgery, Ankara, Turkey
DOI : 10.5137/1019-5149.JTN.16809-15.1 AIM: Leptomeningeal adhesions and fibrosis in the spinal peridural space are the most common causes of post-laminectomy syndrome. Fibrin sealant agents and membrane barriers are commonly used for hemostasis and sealing purposes in spinal surgery. Peridural fibrosis may be a risk of the usage of these topical agents. In this study, we aimed to compare the effects of Cova?, Tisseel« and Adcon«Gel on the development of spinal peridural fibrosis in the experimental rat model.

MATERIAL and METHODS: Thirty-two Sprague Dawley female rats were randomly divided into 4 groups. Groups were constituted as group 1; Cova? group (laminectomy+CovaTM), group 2; Tisseel« group (laminectomy+Tisseel«), group 3; Adcon«Gel group (laminectomy + Adcon«Gel), group 4; control group (laminectomy only). Six weeks after laminectomy, spinal columns were removed en bloc between L1 and L4 vertebrae. Peridural fibrosis was evaluated histologically and the results were compared statistically.

RESULTS: Statistically significant reduction of peridural fibrosis was achieved in groups 1, 2, and 3 when compared with the control group (p<0.05). Our data revealed a statistically significant difference between group 1 and group 3 (p<0.05). When we compared with group 2 and 3, the fibrosis grades were not different between these two groups (p>0.05).

CONCLUSION: Fibrin sealant agent Tisseel« and membrane barrier Cova? do not enhance peridural fibrosis following laminectomy. Cova? and Tisseel« may be appropriate for hemostasis and leakage prevention during the spinal surgery and it is safe to leave these materials on the operation surface. Keywords : Peridural fibrosis, Post-laminectomy syndrome, Failed back surgery syndrome

Corresponding author : Atilla KAZANCI, atillakazanci@gmail.com