Turkish Neurosurgery 2017 , Vol 27 , Num 6
Comparison of the Effects and Mechanism of the Curcumin with Different Drugs in Experimental Vasospasm After Subarachnoid Hemorrhage
Hasan Emre AYDIN1,Nuriye Ezgi BEKTUR2,Zuhtu OZBEK3,Setenay ONER4,Cengiz BAYCU2, Fatma Sultan KILIC5
1Dumlupnar University, Department of Neurosurgery, Kutahya, Turkey
2Osmangazi University, Department of Histology, Eskiehir, Turkey
3Osmangazi University, Department of Neurosurgery, Eskisehir, Turkey
4Osmangazi University, Department of Biostatistics, Eskisehir, Turkey
5Osmangazi University, Department of Pharmacology, Eskisehir, Turkey
DOI : 10.5137/1019-5149.JTN.17432-16.2 AIM: Cerebral vasospasm following subarachnoid hemorrhage (SAH) is the most important complication that effects the mortality and morbidity of patients with intracranial aneurysm. Today, the mechanisms of vasospasm are not understood in spite of experimental and clinical researches. The aim of our study was to investigate the effects of curcumin on vasospasm following SAH.

MATERIAL and METHODS: In this study, 64 rats (200-250 g weight) were divided into 7 groups. Group 1: having no treatment after SAH; Group 2: treatment with nimodipine after SAH; Group 3: treatment with nicorandil after SAH; Group 4: treatment with sildenafil citrate after SAH; Group 5: treatment with 150 mg/kg curcumin after SAH; Group 6: treatment with 300 mg/kg curcumin after SAH, Group 7: treatment with 600 mg/kg curcumin after SAH. The experimental SAH was induced by injection of autologous blood into the cisterna magna. After medical treatment, in the first hour, blood was taken for quantified the levels of TNF-?, IL-1? and IL-6. Then, cerebrum and cerebellum were removed for analysis. Basilar artery luminal diameter was measured and apoptotic cell count was performed with tissue samples.

RESULTS: Histopathological findings showed that, in sufficient dose, curcumin dilated the basilar artery beside anti-oxidant effect.

CONCLUSION: Curcumin can be used for the treatment of vasospasm as a new medical drug. Keywords : Curcumin, Nicorandil, Nimodipine, Sildenafil citrate, Subarachnoid hemorrhage

Corresponding author : Hasan Emre AYDIN, dremreaydin@gmail.com