Turkish Neurosurgery 2016 , Vol 26 , Num 4
Prognostic Value of Angiogenesis and Survivin Expression in Patients with Glioblastoma
Ebru TASTEKIN1, Vuslat Yurut CALOGLU2, Fulya OZ PUYAN1, Burcu TOKUC3, Murat CALOGLU2, Tulin Deniz YALTA1, Nuray CAN1, Beril GULER1
1Trakya University, School of Medicine, Department of Pathology, Edirne, Turkey
2Trakya University, School of Medicine, Department of Radiation Oncology, Edirne, Turkey
3Trakya University, School of Medicine, Department of Public Health, Edirne, Turkey
DOI : 10.5137/1019-5149.JTN.16552-15.1 AIM: Glioblastoma (GBM) is the most common and the most aggressive primary brain tumor with poor prognosis. We aimed to evaluate the association between immunohistochemical expression of survivin and angiogenic parameters (microvessel density and vascular pattern) in patients who underwent surgery for GBM.

MATERIAL and METHODS: The pathology reports and also clinical and follow-up data of patients with GBM were retrospectively evaluated. Control tissues were obtained from the archive for each antibody (Survivin, CD 34). Then, control staining of these antibodies was performed. Vessels were evaluated according to the standardized assessment of vascular pattern.

RESULTS: Mean survival for classical vascular pattern was longer than bizarre vascular pattern (p<0.001). The survival time of patients decreased with increasing score of survivin staining. There was a significant correlation between survivin and survival time (p<0.001). There was no significant correlation between microvessel density and survival time (p>0.05).

CONCLUSION: With these findings, it is considered that high expression of survivin, bizarre vascular pattern and development of secondary GBM correlates with the low survival rates, however microvessel density has no correlation with the survival rates. Since only malignant cells express survivin, it might be a target protein for the development of novel therapies. Keywords : Glioblastoma, Survivin, Vascular pattern, Survival

Corresponding author : Ebru Tastekn, ebrutastekin@hotmail.com