Turkish Neurosurgery 2016 , Vol 26 , Num 2
Experimental Endoscopic Cordotomy in the Sheep Model
Ali DALGIC1, Murat CALISKAN2, Pinar CAN2, Fatih ALAGOZ1, Yahya GUVENC1, Ayhan OCAKCIOGLU1, Oktay ALGIN3, Ergun DAGLIOGLU1, Esra ERDEN4, Omer BESALTI2, Deniz BELEN1
1Ankara Numune Educational and Training Hospital, Neurosurgery Clinic, Ankara, Turkey
2Ankara University, School of Veterinary Medicine, Department of Surgery, Ankara, Turkey
3Ataturk Research and Training Hospital, Radiology Clinic, Ankara, Turkey
4Ankara University, School of Medicine, Department of Pathology, Ankara, Turkey
DOI : 10.5137/1019-5149.JTN.12229-14.1 AIM: Interventional pain therapies are usually based on destruction of the related pain-conducting pathways. Current procedures targeting pain have replaced conventional pain treatment modalities while being less invasive. In this study, we investigated the feasibility of the endoscopic percutaneous cordotomy process on the sheep cervical spinal cord.

MATERIAL and METHODS: Seven male sheep, Akkaraman genus, were operated on in the study. The guide was introduced at C1 to C2 vertebrae. The interlaminar area was exposed by a dilator, the dura was identified, and then the working cannula was inserted into the subarachnoid space. The target point of cordotomy was defined by endoscopic visualization as the midpoint between the dentate ligament and ventral root entry zone. After determination of the target point, a carbon dioxide laser (CDL) probe was introduced through the cannula. Ablative lesioning was performed by CDL. Hindlimb withdrawal thresholds were measured using the “Sample Pain Scale”. The lesion was demonstrated by magnetic resonance imaging and histopathological examination.

RESULTS: Three sheep had ipsilateral hemiparesis and the response to firm pressure test was not performed on them. Among the remaining four sheep, the pain tolerance test showed that one sheep was at stage 0, two at stage 1, and the last one at stage 3.

CONCLUSION: Cordotomy might be successfully performed with the endoscopic technique in the sheep model and this should encourage future studies regarding minimal invasive procedures for intractable pain. Keywords : Cordotomy, Percutaneous technique, Endoscopy, Sheep

Corresponding author : Ali Dalgc, alidalgic@yahoo.com