Turkish Neurosurgery 2016 , Vol 26 , Num 2
Evaluation of the Association Between Matrix Metalloproteinase 11 and Intervertebral Disc Disease
Adem Bozkurt ARAS1, Mustafa GUVEN1, Naci BALAK2, Erdo­an AYAN3, Suheyla BOZKURT UYAR4, Ilhan ELMACI5
1Canakkale Onsekiz Mart University, School of Medicine, Department of Neurosurgery, Canakkale, Turkey
2G÷ztepe Education and Research Hospital, Department of Neurosurgery, Istanbul, Turkey
3Trakya University, School of Medicine, Department of Neurosurgery, Edirne, Turkey
4Marmara University, Institute of Neurological Sciences, Department of Pathology, Istanbul, Turkey
5Medipol University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.12762-14.0 AIM: The intervertebral disc starts to degenerate when a human being begins to stand and learn to walk. It is known that many extrinsic, intrinsic and genetic factors play a role in disc degeneration. In this study, we examined whether the matrix metalloproteinase 11 might be associated with intervertebral disc degeneration.

MATERIAL and METHODS: Fifty-six patients with lumbar disc herniations who were operated at G÷ztepe Education and Research Hospital, Neurosurgery Clinic between September 2008 and December 2009 were prospectively reviewed. History and complaints were obtained from the case reports. Neuroradiological evaluation was performed with magnetic resonance imaging. Surgical findings of cases were reported in the operation notes. Microscopic posterior hemipartial laminectomy and discectomy were performed in all cases. Degenerated herniated disc material of all cases extracted during surgery was evaluated with immunohistochemical staining in Marmara University, Institute of Neurological Sciences, Pathology Laboratory.

RESULTS: Comparing the immunohistochemical staining of cases who were 50 years or younger and cases who were over 50 years old, statistical significance was determined.

CONCLUSION: Matrix metalloproteinase 11 has a role in degenerating intervertebral disc disease, but it is not the only factor. Matrix metalloproteinase 11 might be a genetic factor in young-middle aged patients. Keywords : Intervertebral disc degeneration, Intervertebral disc displacement, Matrix metalloproteinase 11, Middle age

Corresponding author : Adem Bozkurt Aras, adem_aras@yahoo.com