Turkish Neurosurgery 2015 , Vol 25 , Num 6
Macrocerebellum: Volumetric and Diffusion Tensor Imaging Analysis
Izlem IZBUDAK1, Niyazi ACER2, Andrea PORETTI3, Kazim GUMUS4, Gokmen ZARARSIZ5
1The Johns Hopkins Hospital, School of Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Section of Pediatric Neuroradiology, Baltimore, USA
2Erciyes University, School of Medicine, Department of Anatomy, Kayseri, Turkey
3The Johns Hopkins University, School of Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, Division of Pediatric Radiology, Section of Pediatric Neuroradiology, Baltimore, USA
4Erciyes University, School of Medicine, Department of Biophysics, Kayseri, Turkey
5Erciyes University, School of Medicine, Department of Biostatistics, Kayseri, Turkey
DOI : 10.5137/1019-5149.JTN.11567-14.0 Macrocerebellum is a rare entity characterized by an enlarged cerebellum. We describe a case of a 48-month-old child with macrocerebellum. We performed serial volumetric analysis [total brain volume (TBV) and cerebellar volume] over a period of 4 years. We analyzed the white matter microstructure in the cerebellum using diffusion tensor imaging (DTI). In our patient, we found higher fractional anisotropy (FA) and lower mean diffusivity (MD) in the cerebellar white matter compared to age-matched controls. Our results may represent accelerated myelination secondary to the abnormal cerebellar development. Keywords : Macrocerebellum, Cerebellar volume, Total brain volume, Volume ratio, Diffusion tensor imaging
Corresponding author : Izlem Izbudak, iizbuda1@jhmi.edu