Turkish Neurosurgery 2015 , Vol 25 , Num 5
Use of Spongostan™ for Prevention of Cranial Subdural Adhesions Following Craniotomy in an Experimental Rabbit Model
Cagatay OZDOL1, Fatih ALAGOZ2, Ali Erdem YILDIRIM2, Murat KORKMAZ3, Ergun DAGLIOGLU2, Pergin ATILLA4, Sevda MUFTUOGLU4, Ahmet Deniz BELEN2
1Antalya Education and Research Hospital, Department of Neurosurgery, Antalya, Turkey
2Ankara Numune Education and Research Hospital, Department of Neurosurgery, Ankara, Turkey
3Kutahya Evliya Celebi Education and Research Hospital, Department of Neurosurgery, Kutahya, Turkey
4Hacettepe University of Medical School, Department of Histology and Embryology, Ankara, Turkey
DOI : 10.5137/1019-5149.JTN.10891-14.1 AIM: Spongostan™ is a sterile, water-insoluble, porcine gelatin absorbable sponge, which is widely used as a hemostatic material. The aim of this study is to test the anti-fibrotic capacity of Spongostan™, using a craniotomy model in an experimental rabbit model.

MATERIAL and METHODS: Eighteen rabbits were divided into two groups: Each group consisted of 9 rabbits, duratomy plus Spongostan™ (group 1), and duratomy without Spongostan™ (group 2). Right parietal bone was removed via trephine and low speed drill and dura was opened. On the group 1 rabbits, an appropriate piece of Spongostan™ was meticulously placed under dural layer. On group 2 rabbits, same procedures were repeated without Spongostan™. Histological sections were taken from each group and evaluated for degree of fibrosis and collagen fibers.

RESULTS: There was marked increase in number of fibroblasts and collagen fibers in group 2 rabbits, however most of the rabbits in Spongostan™ group demonstrate scarce histopathological findings for fibrosis.

CONCLUSION: We conclude that an appropriately placed subdural Spongostan™ over cerebral tissue may prevent postoperative surgical adhesions after neurosurgical operations. Keywords : Craniotomy, Rabbits, Spongostan™ , Subdural fibrosis, Surgery

Corresponding author : Ergun Daglřoglu, ergundaglioglu@gmail.com