Turkish Neurosurgery 2015 , Vol 25 , Num 5
The Effect of Levetiracetam on Closure of the Midline in Early Chicken Embryos
1Ankara University, School of Medicine, Department of Neurosurgery, Ankara, Turkey
2Medical Park Hospital, Department of Neurosurgery, Elazig, Turkey
DOI : 10.5137/1019-5149.JTN.8514-13.4 AIM: Genetic predisposition and some environmental factors play an important role in the development of neural tube defects. Levetiracetam is a new drug that has been approved in the treatment of partial seizures. We aimed in this study to determine the effect of levetiracetam on chick embryos.

MATERIAL and METHODS: One hundred and sixty fertile non-pathogenic Super Nick eggs were incubated for 24 hours and were divided into four groups of 40 eggs each. Levetiracetam was administered via the sub-blastodermic route. The eggs were incubated for another 24 hours. All eggs were opened at the 48th hour, and the embryos were evaluated morphologically and histopathologically.

RESULTS: The effects of levetiracetam on the embryo were correlated with the dose of levetiracetam. In the light of the results, it was determined that the use of increasing doses of levetiracetam led to defects of midline closure in early chicken embryos.

CONCLUSION: Levetiracetam, a new antiepileptic drug that is effective especially on calcium ion concentration, leads to defects in midline closure in embryos in a dose-dependent manner. Further studies are needed to show the mechanism of embryonic damage and the mechanisms of its teratogenous effects associated with genetic and environmental factors. Keywords : Levetiracetam, Calcium, Neural tube defect, Chicken embryo

Corresponding author : Onur Ozgural, onurozgural@yahoo.com