Turkish Neurosurgery 2015 , Vol 25 , Num 2
Local Application of Corticosteroids Combined with Surgery for the Treatment of Chronic Subdural Hematoma
Xiao-Ping XU, Cong LIU, Jian LIU, Yuan-Guang PANG, Xu-Dong LU O, Jun FU, Liang ZHOU, Ying-Zhong FAN
The First People’s Hospital of Neijiang, Department of Neurosurgery, Neijiang, Sichuan, China DOI : 10.5137/1019-5149.JTN.8989-13.3 AIM: Combination treatment consisting of surgery and pre-or post-operative corticosteroids for chronic subdural hematoma (CSH) tend to have better outcomes than surgery only. However, there are many complications after long-term use of corticosteroids. In this study, we evaluated the clinical outcomes of local application of corticosteroids combined with surgery for CSH.

MATERIAL and METHODS: We retrospectively analysed the data of the patients undergoing surgery and local application of Methylprednisolone Sodium Succinate for Injection (MPSS) into the hematoma cavity. Neurological status was assessed by Markwalder’s Grading Scale (MGS). Recurrence was defined as deteriorating neurological status with radiological evidence of reaccumulation.

RESULTS: A total of 26 patients were enrolled in this study. During the follow-up period, all patients made excellent neurological recovery. 24 (92.3%) patients’ MGS was grade 0 at 12 months after the surgery. There was no mortality or recurrence. 5 patients (19.2%) suffered postoperative complications, of which 2 developed some subdural air collection, 2 had a partial seizure attack and 1 developed an acute epidural hemorrhage.

CONCLUSION: The results suggest that local application of MPSS combined with surgery is a safe and effective method in the management of CSH. It may reduce hematoma recurrence. Keywords : Chronic subdural hematoma, Surgery, Corticosteroids, Local application

Corresponding author : Cong L U, njyyliucong@163.com