Turkish Neurosurgery 2015 , Vol 25 , Num 1
The Relation of Matrix Metalloproteinase 1, 2, 3 Expressions with Clinical and Radiological Findings in Primary and Recurrent Lumbar Disc Herniations
Seyma OZKANLI1, Tuncay KANER2, Mustafa EFENDIOGLU3, Recep BASARAN3, Mehmet SENOL2, Ebru ZEMHERI1, Ahmet Ferruh GEZEN2
1Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Pathology, Istanbul, Turkey
2Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey
3Dr. Lutfi Kirdar Kartal Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.11276-14.1 AIM: In this study, our aim was to examine if matrix metalloproteinase expressions (MMP-1, MMP-2, MMP-3) in patients operated with a lumbar disc hernia diagnosis are different in terms of clinical and neuroradiological findings.

MATERIAL and METHODS: The study included 80 patients treated with micro discectomy for lumbar disc hernia. Degeneration was scored via magnetic resonance (MR) images. MMP-1, MMP-2, and MMP-3 antibodies were used for immunohistochemical evaluation of degenerated disc materials. MMP expressions were compared between primary and recurrent cases, and correlation analysis was conducted.

RESULTS: Discectomy material showed higher expression of MMP-1 and MMP-3 in cases of recurrent lumbar disc herniation than in primary herniation. There was no significant relationship between MMP expression and MR degeneration score.

CONCLUSION: MMP-1 and MMP-3 expressions were significantly higher in recurrent cases in terms of magnetic resonance degeneration score. We assume that the higher co-expression of MMP-1 and MMP-3 might be used in targeted treatment regiemens in patients with recurrent LDH. Keywords : Lumbar disc herniation, Matrix metalloproteinase, Pfirrmann classification, Recurrent disc herniation

Corresponding author : Tuncay Kaner, tuncaykaner@gmail.com