Turkish Neurosurgery 2015 , Vol 25 , Num 1
Antiedema Effects of Proanthocyanidin on Experimental Traumatic Brain Edema
Yavuz ERDEM1, Ayhan TEKINER2, Yavuz Selim ERKOC3, Muhammet Bahadřr YILMAZ2, Haydar CELIK1, Ali Erdem YILDIRIM4, Ayse Selda TEKINER5, Mehmet Akif BAYAR1
1Ankara Training and Research Hospital, Department of Neurosurgery, Ankara, Turkey
2Kayseri Training and Research Hospital, Department of Neurosurgery, Kayseri, Turkey
3Sanlřurfa Training and Research Hospital, Department of Neurosurgery, Sanlřurfa, Turkey
4Ankara Numune Training and Research Hospital, Department of Neurosurgery, Ankara, Turkey
5Ankara University, School of Medicine, Department of Family Medicine, Ankara, Turkey
DOI : 10.5137/1019-5149.JTN.10359-14.2 AIM: Brain edema developing due to central nervous system trauma is still a significant reason of mortality and morbidity. There is still no definite approach for the medical treatment of brain edema despite many clinical and laboratory studies in recent years. We therefore investigated the effect of proanthocyanidin, an antioxidant agent, on brain edema in this study.

MATERIAL and METHODS: A total of 30 rats were used and divided into three as the control, trauma and treated trauma groups. Subjects were sacrificed after 72 hours. The brain tissue-water ratio was evaluated and biochemical analysis of brain tissue performed.

RESULTS: The difference between the treated trauma and control groups was statistically significant while the trauma and control groups were relatively similar. Rats that had undergone trauma and received proanthocyanidin treatment were statistically significant and different from the trauma group rats regarding the biochemical analysis results, brain tissue water ratio, and the cold damage enzymatic antioxidant defense system of cortical neural tissue.

CONCLUSION: We believe that proanthocyanidin, an antioxidant substance, can be an effective treatment for brain edema. Keywords : Brain edema, Proanthocyanidin, Head trauma

Corresponding author : Ayhan Tekřner, tekinerayhan38@gmail.com