Turkish Neurosurgery 2014 , Vol 24 , Num 5
A Case of Fatal Late Vasospasm in a Patient with a Recurrent, Supratentorial Rhabdoid Primitive Neuroectodermal Tumor: Possible Molecular Implications
Massimo MISCUSI1, Luca De MARTINO2, Manila ANTONELLI3, Giorgio MANGINO1, Luca RICCIARDI1, Gianpaolo SPINELLI1, Stefano FORCATO2, Antonella CALOGERO1, Vincenzo PETROZZA1, Giuseppe RAGONA1, Antonino RACO1
1Sapienza University of Rome, Medico-Surgical Sciences and Biotechnologies, Latina, Italy
2Sapienza University of Rome, NESMOS, Rome, Italy
3Sapienza University of Rome, Department of Pathology, Rome, Italy
DOI : 10.5137/1019-5149.JTN.9388-13.1 We report the case of a 44-year-old man who experienced a fatal and untreatable delayed vasospasm after resection of a recurrent temporal IV grade primitive neuroectodermal tumor (PNET). The histological analysis demonstrated a rare rhabdoid variant of the tumor with a diffuse myxoid degeneration; molecular investigations demonstrated an upregulation of IL-1β and IL-6 expression in the recurrence.

We reviewed the pathophysiology of the vasospasm that occurs after tumors resection, and due to the rarity of case, we speculated on the possibility that specific histological and molecular features of the tumor could have contributed to the delayed and fatal complication. Keywords : PNET, Rhabdoid cells, Complication, Cerebral ischemia, Vasospasm

Corresponding author : Massimo Mřscusř, m.miscusi@libero.it