Turkish Neurosurgery 2014 , Vol 24 , Num 5
Prognostic Factors Obtained from Long-Term Follow-up of Pituitary Adenomas and Other Sellar Tumors
Halit DIRI1, Ersin OZASLAN2, Ali KURTSOY3, Bulent TUCER3, Yasin SIMSEK1, Figen OZTURK4, Ahmet Candan DURAK5, Fahri BAYRAM1
1Erciyes University, School of Medicine, Department of Endocrinology, Kayseri, Turkey
2Erciyes University, School of Medicine, Department of Medical Oncology, Kayseri, Turkey
3Erciyes University, School of Medicine, Department of Neurosurgery, Kayseri, Turkey
4Erciyes University, School of Medicine, Department of Pathology, Kayseri, Turkey
5Erciyes University, School of Medicine, Department of Radiology, Kayseri, Turkey
DOI : 10.5137/1019-5149.JTN.9140-13.1 AIM: Pituitary adenomas do not have a single factor of aggressive behavior or recurrence. The objective of this study was to determine factors influencing the prognosis in pituitary adenomas.

MATERIAL and METHODS: 243 patients who were operated between January 2000 and June 2012 were included in this retrospective study. Demographic data, age at diagnosis, date of diagnosis, date of operation, type of operation, post-operative medications, pre- and postoperative hormone levels, and MRI findings were evaluated in each patient.

RESULTS: The rate of total resection of sellar tumors was less than 50% in our patient population. The prognosis was better in cases with total resection. Tumor size was a poor prognostic factor in sellar tumors. Female sex was a poor prognostic factor in acromegaly and male sex in prolactinoma. The prognosis was worse in patients with cavernous sinus invasion. In acromegaly, pre-operative level of 850 ng/ml for IGF-1 was noted as a possible prognostic cut-off value.

CONCLUSION: Long-term follow-up results of our study suggest that factors common to all sellar tumors including tumor type, tumor size, total resection, and cavernous sinus invasion and tumor type-specific factors including sex and hormone levels play important roles in the prognosis. Keywords : Pituitary adenoma, Sellar region tumor, Prognosis, Follow-up

Corresponding author : Halit Dr, halitdiri@yahoo.com