Turkish Neurosurgery 2013 , Vol 23 , Num 2
Dose Dependent Morphological Effects of Alpha Lipoic Acid on Vasospastic Femoral Artery in Rats
Tugrul TON1, Aysegul OZDEMIR OVALIOGLU1, Ozlem TON2, Turgay BILGE1, Talat KIRIS3
1Haseki Education and Research Hospital, Department of Neurosurgery, Istanbul, Turkey
2Sisli Etfal Education and Research Hospital, Department of Pathology, Istanbul, Turkey
3Istanbul University, Istanbul Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.5893-12.1 AIM: The dose dependent effects of alpha lipoic acid (α-LA) were investigated morphologically on rat vasospasm model.

MATERIAL and METHODS: 32 rats were divided into four groups: group I=control; group II=vasospasm; group III=vasospasm +low dose (20 mg/kg) intraperitoneal α-LA administered; and group IV=vasospasm +high dose (100 mg/kg) intraperitoneal α-LA administered. Histological and morphometric examinations were carried out for each groups under light microscope.

RESULTS: The mean vascular wall thickness displayed significant increase in group II and III compared with group I (p<.05). Statistical comparison of group II and IV, regarding vascular wall thickness showed a significant decrease in group IV, and regarding vascular lumen area showed a significant increase in group IV (p<.05).

CONCLUSION: It is demonstrated α-LA reduces the effects of vasospasm in high dose treatment group by decreasing the wall thickness and increasing the lumen surface area. The present study suggests that adequate dose of α-LA is a potential therapeutic agent in experimental vasospasm model. Keywords : Alpha lipoic acid, Cerebral vasospasm, Rat femoral artery, Subarachnoid hemorrhage

Corresponding author : Ay■egul Ozdemřr Ovalřoglu, draysegulozdemir@yahoo.com