Turkish Neurosurgery 2012 , Vol 22 , Num 6
Is There a Relationship Between Serum Heart- Type Fatty Acid Binding Protein Level and Clinical Severity in Patients with Subarachnoid Hemorrhage?
Metehan YILMAN1, Cengiz COKLUK2, Ahmet BAYDIN1, Turker YARDAN1, Celal KATI1, Murat GUNAY3, Murat MERIC4
1Ondokuzmayis University, Faculty of Medicine, Department of Emergency, Samsun, Turkey
2Ondokuzmayis University, Faculty of Medicine, Department of Neurosurgery, Samsun, Turkey
3Ondokuzmayis University, Faculty of Medicine, Department of Biochemistry, Samsun, Turkey
4Ondokuzmayis University, Faculty of Medicine, Department of Cardiology, Samsun, Turkey
DOI : 10.5137/1019-5149.JTN.5847-12.2 AIM: The aim of this study was to determine the serum heart-type fatty acid binding protein (H-FABP) levels and cardiac effects in patients presenting with subarachnoid hemorrhage (SAH) and to investigate whether any correlation exists between the cardiac effects and H-FABP.

MATERIAL and METHODS: Forty-six patients diagnosed as acute SAH in the emergency department were included in this study. Twenty healthy adults were included in the study to serve as controls. Twelve-lead ECG was performed on all patients on admission. H-FABP levels of patients were determined in serum samples taken on admission.

RESULTS: Serum H-FABP levels of patients were found to be significantly higher than those of controls (p<0.05). There was no significant correlation between serum H-FABP levels and ECG changes. There was a moderate positive correlation between H-FABP serum levels and the grade according to the Hunt and Hess classification (r=0.43, p<0.05). There was a weak positive correlation between H-FABP serum levels and the grade according to the Fisher radiological classification (r=0.38, p<0.05).

CONCLUSION: Serum H-FABP levels are increased in patients with SAH. Grades according to the Hunt and Hess and Fisher grading scales were shown to increase in conjunction with an increase in H-FABP levels. Keywords : Subarachnoid hemorrhage, Electrocardiography, Clinical severity, H-FABP

Corresponding author : Ahmet Baydřn, abaydin@omu.edu.tr