Turkish Neurosurgery 2011 , Vol 21 , Num 4
The Effect of Choroidal Artery Vasospasm on Choroid Plexus Injury in Subarachnoid Hemorrhage: Experimental Study
Adem YILMAZ1, Mehmet Dumlu AYDIN2, Ayhan KANAT3, Ahmet Murat MUSLUMAN1, Sare ALTAS4, Yunus AYDIN1, Muhammet CALIK4, Nesrin GURSAN4
1Sisli Etfal Education and Research Hospital, Department of Neurosurgery, Istanbul, Turkey
2Ataturk University, Faculty of Medicine, Department of Neurosurgery, Erzurum, Turkey
3Rize University, Faculty of Medicine, Department of Neurosurgery, Rize, Turkey
4Ataturk University, Faculty of Medicine, Department of Pathology, Erzurum, Turkey
DOI : 10.5137/1019-5149.JTN .4204-11.1 AIM: We examined whether vasospasm of choroidal arteries (ChAs) may be resulted in ischemic injury in choroid plexus (CP) after subarachnoid hemorrhage (SAH).

MATERIAL and METHODS: This study has been conducted on 30 rabbits. Eight, fourteen and eight of them were used as control, SAH and SHAM groups, respectively. The volumes of choroidal arteries were examined and measured by using the micrometric microscope barr. Ischemic morphological changes of the choroid plexus cells and villus were examined as follows: cellular shrinkage (1 point), cytoplasmic condensation (2 points), angulation (3 points) and villus desquamation (4 points) were considered as 1st, 2nd, 3rd, 4th degree downward choroid plexus degeneration criteria. Degeneration scores of 1 to 4 criteria were calculated by summing the exacerbated ones with the existing one.

RESULTS: Choroidal artery diameter&volume, and CP degeneration scores in three groups were evaluated: The mean volumes were 1.080±0.650mm3, 0.907±0.330 mm3, 0.480±0.175 mm3 and the degeneration scores of choroidal plexuses were scored as 0 and 1- 1, and 4- 3 and 10 in the control, SHAM and SAH groups respectively. A significant correlation between the degree of vasospasm and CP degeneration was found.

CONCLUSION: Vasospasm of choroidal arteries may be at a serious degree in cases with SAH incurs damages on choroid plexuses, and affects structures which play important roles in immune, endocrine, detoxifying, thermoregulatory, and secretory functions of the brain resulting in worsened prognosis. Keywords : Choroidal artery, Vasospasm, Choroid plexus injury, Subarachnoid hemorrhage, Rabbit

Corresponding author : Mehmet Dumlu Aydın, nmda11@hotmail.com