Turkish Neurosurgery 2011 , Vol 21 , Num 3
The Effects of Analgesia-Sedation on the Immune System before and after Cerebral Digital Subtraction Angiography
Ercan TURECI1, Osman KIZILKILIC2, Sibel AKYOL3, Ferit PEKEL1, Taner TANRIVERDI4, Murat HANCI4, Mois BAHAR1
1Istanbul University, Cerrahpasa Faculty of Medicine, Department of Anesthesiology and Reanimation, Istanbul, Turkey
2Istanbul University, Cerrahpasa Faculty of Medicine, Department of Radiology, Istanbul, Turkey
3Istanbul University, Cerrahpasa Faculty of Medicine, Department of Physiology, Istanbul, Turkey
4Istanbul University, Cerrahpasa Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.4296-11.1 AIM: Cerebral digital subtraction angiography (DSA) is an invasive procedure and may cause inflammatory responses in the body. This study aims to provide cytokine and lymphocyte profile in a population of patients underwent cerebral DSA.

MATERIAL and METHODS: Forty-one male patients who admitted for cerebral DSA were included in this study. Patients were divided into two groups: Group I (n = 7) included patients who did not receive analgesia-sedation and group II (n = 34) received analgesia-sedation before procedure. For the molecules, a venous blood samples from every patient was collected before and after cerebral DSA.

RESULTS: Cytokine levels in group I showed a trend to increase in the majority of the molecules after the procedure except IL-1β. In group II, cytokines showed variable trend. When comparing the two groups regarding cytokine levels after cerebral DSA, IL-1β, IL-10, IL-12, and IFN-γ levels increased significantly in group II. Comparing the two groups with respect to lymphocytes after cerebral DSA showed that CD56 levels were significantly higher in group II and other parameters did not show significant differences.

CONCLUSION: It can be possible that delimitation of the action(s) of the cytokines affecting the secretion or activation of CD56 (natural killer) may avoid complications of inflammation after invasive procedures. Keywords : Angiography, Cerebrum, Cytokine, Inflammation, Lymphocytes, Immune system

Corresponding author : Osman Kızılkılıc, osmank@istanbul.edu.tr