Turkish Neurosurgery 2010 , Vol 20 , Num 4
Radiological and Histopathological Comparison of Microporous Polysaccharide Hemospheres and Oxidized Regenerated Cellulose in the Rabbit Brain: A Study of Efficacy and Safety
Hakan EMMEZ1, Mehmet TONGE2, Nil TOKGOZ3, Emre DURDAG4, Ipek GONUL5, Necdet CEVİKER6
1,2,4,6Gazi University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey
3Gazi University, Faculty of Medicine, Department of Radiology, Ankara, Turkey
5Gazi University, Faculty of Medicine, Department of Pathology, Ankara, Turkey
DOI : 10.5137/1019-5149.JTN.3300-10.2 Aim: Topical hemostatic agents are widely used in brain surgery but they have some disadvantages such as foreign body reaction, being a focus for infection and causing artifacts in radiological examinations. The purpose of this study is to compare the effectiveness and safety of microporous polysaccharide hemospheres (MPH) with a well known agent, oxidized regenerated cellulose (ORC), histopathologically and radiologically.

Material and Methods: Standard brain lesions (4x1mm) were created in 24 hemispheres in 12 New-Zealand rabbits. Animals were divided into three groups; control, ORC and MPH. Twenty-four hours later, all rabbits magnetic resonance brain imaging. After imaging, the animals were sacrificed and the brains were removed for histopathological analysis.

Results: Histopathological analysis showed no significant difference between the groups. Radiological examination showed no significant difference between the MPH and ORC groups in terms of edema but the edema in control group was significantly prominent than MPH and ORC groups (p<0.001).

Conclusion: A new agent (MPH) provides safe and effective hemostasis in the brain in this study. The most important advantage of microporous polysaccharide hemospheres is their rapid clearance from the surgical field and therefore having the potential of causing less imaging artifacts. Keywords : Brain hemorrhage, Hemostasis, Magnetic resonance, Microporous polysaccharide hemospheres, Oxidized regenerated cellulose

Corresponding author : Mehmet Tonge, tonge_m@yahoo.com