Turkish Neurosurgery 2005 , Vol 15 , Num 3
Histopathology, Invasion, Migration and Tumorigenicity in the C6 Rat Glioma Model
Department of Neurosurgery, Bakırköy Training and Research Hospital for Psychiatric and Neurological Diseases, İstanbul, Turkey Glial tumors are the largest group of central nervous system tumors and glioblastoma multiforme is the most common form. Glioblastomas are anaplastic forms of gliomas. Their high incidence and malignity have led researchers to work hard to better understand and treat these tumors. It is now known that genetic factors play a role in glioma etiopathogenesis. Of the differences in genetic built, two attract the most attention: oncogenes that lead to cell division and the occurrence of cells that have lost tumor suppressor genes. After realizing that the evolution of surgery and radiotherapy would have no significant value for malignant brain tumors, the trial of potential chemotherapeutic, genetic and immunologic therapy methods in an appropriate experimental glioma model has gained in importance. The C6 rat glioma model is used in these studies because of its similarity to the human glioblastoma. In this study, we used the C6 rat glioma model which has glioblastoma-like effects and tried to understand these tumors better by detecting their tumorigenicity, invasion and migration characteristics in the research laboratory of our clinic. Keywords : C6 rat glioma, migration, invasion, histopathology
Corresponding author : Çağatay Kemerli, cagataykemerli@hotmail.com