Turkish Neurosurgery 2023 , Vol 33 , Num 4
Continuous SGB Inhibits Occurrence and Maintenance of Mechanical Hyperalgesia via Reducing Inflammatory Cytokines in Striatum and PAG of PD Nociception Rat Models
Min LI1,Wen HUANG3,Yan SHI4,Ying ZENG4,Ge LIU1
1Fuzong Clinical Medicine College of Fujian Medical University, 900 Hospital of the Joint Logistics Support Force, Department of Anesthesiology and Perioperative Medicine, Fuzhou, 350025, Fujian, China
2Xiamen University, Dongfang Hospital, Department of Anesthesiology and Perioperative Medicine, Fuzhou, 350025, Fujian, PR China
3Shangrao Municipal Hospital, Department of Anesthesiology, Shangrao, P.R. China
4Ningde Municipal Hospital of Ningde Normal University, Department of Anesthesiology, Ningde 352100, Fujian, PR China
DOI : 10.5137/1019-5149.JTN.38254-22.2 AIM: To investigate the effect of stellate ganglion block (SGB) on nociception in Parkinson?s disease (PD) rat models, and to clarify the associated mechanism.

MATERIAL and METHODS: To generate PD nociception rat model 6-hydroxydopamine (6-OHDA) injection method was used. Paw withdrawal threshold (PWT) and paw retraction latency (PWL) was used to reflect mechanical stimulation and thermal stimulation, respectively, at pre-modeling and 1, 2, 3, 4 weeks post modeling. The preventive and therapeutic effects of SGB treatment on nociception were observed in Naive, Vehicle, and 6-OHDA group (model). Levels of IL-1?, IL-6, and TNF-? in striatum and periaqueductal gray (PAG) were detected with ELISA.

RESULTS: 6-OHDA injection induced obvious reduction of bilateral PWT from 2 to 4 weeks post modeling, suggesting that PD nociception rat model was successfully established. Continuous SGB prevention inhibited mechanical hyperalgesia at 2, 3 and 4 weeks post modeling, and significantly reversed mechanical hyperalgesia at 3 and 4 weeks post modeling, compared with those of Saline group (p<0.05). These results suggest that continuous SGB could effectively prevent and alleviate pain of PD rats. SGB treatment remarkably suppressed levels of inflammatory factors (IL-1 ?, IL-6, and TNF-?) in striatum and PAG of PD rats compared with those of rats in Vehicle group (p<0.05).

CONCLUSION: Continuous SGB effectively inhibited and reversed mechanical hyperalgesia of PD nociception rats through inhibiting inflammatory response in striatum and PAG. Keywords : Parkinson?s disease, Stellate ganglion block, Pain, Mechanical hyperalgesia, Inflammatory factors, Rats

Corresponding author : Ge LIU, lm13905009412@163.com