Turkish Neurosurgery 2023 , Vol 33 , Num 1
Maternal Serum and Fetal Cord Blood Concentrations of Thiol/ Disulfide and Ischemia-Modified Albumin as Predictors of Neural Tube Defects
Ozgur OCAL1,Fatma Doga OCAL2,Selcan SINACI2,Zeynep DAGLAR1,Ahmet Eren SECEN1,Denizhan DIVANLIOGLU1,Esra Fırat OGUZ3,Ozcan EREL3,Cuneyt TAYMAN4,Dilek SAHIN2,Ahmet Deniz BELEN1,Ali DALGIC1
1Ankara City Hospital, Department of Neurosurgery, Ankara, Turkey
2Ankara City Hospital, Department of Perinatology, Ankara, Turkey
3Ankara Yildirim Beyazit University, Department of Biochemistry, Ankara, Turkey
4Ankara City Hospital, Department of Pediatrics, Ankara, Turkey
DOI : 10.5137/1019-5149.JTN.40096-22.3 AIM: To investigate the predictive role of thiol/ disulfide homeostasis and Ischemia-modified albumin (IMA) levels for NTDs.

MATERIAL and METHODS: A total of 71 pregnant women (31 with NTD and 42 healthy controls) were enrolled in this study. This prospective case-control study included pregnant women with NTDs as the study group and randomly selected age-matched pregnant women with healthy fetuses as the control group. The two groups were compared on the basis of thiol/disulfide and IMA levels in the maternal and fetal samples.

RESULTS: No statistically significant difference in native thiol, total thiol, disulfide, and calculated ratios was observed between the groups. However, maternal IMA values were significantly higher in the study group. The IMA was proven to be a predictor with a sensitivity of 77.4% and specificity of 100% for NTDs at a cut-off value of 1.32.

CONCLUSION: The examination of the maternal levels of IMA may be useful in the detection of NTDs. Keywords : Neural tube defects, Ischemia-modified albumin, Thiol/disulfide, Oxidative stress

Corresponding author : Fatma Doga OCAL, eadoga@yahoo.com