Turkish Neurosurgery 2023 , Vol 33 , Num 1
LNC01296 Regulates Apoptosis Genes Birc2 and Bak1 by Targeting miRNA-29c and Participates in Neuroprotection During Cerebral Ischemia/Reperfusion Injury in Rats
Lingjie MENG1,Yuanpu QI1,Ke DU1,Xiaoyu ZHANG2
1Zhengzhou Railway Vocational and Technical College, Rehabilitation and Treatment Major, Zhengzhou, Henan, China
2Fuzhou Medical College of Nanchang University, Fuzhou, Jiangxi, China
DOI : 10.5137/1019-5149.JTN.36564-21.1 AIM: To explore the extent to which LNC01296 inhibits the miRNA-29c expansion genes Birc2 and Bak1 from causing damage induced by brain expansion and reimplantation.

MATERIAL and METHODS: A total of 120 adult male experimental rats were divided to verify the effects of miRNA-29c and LNC01296 on brain expansion/reimplantation injury.

RESULTS: miRNA-29c can inhibit the Birc2/Bak1 pathway and aggravate the brain expansion/reimplantation damage. LNC01296 blocks miRNA-29c from entering the brain to protect it from expansion after reimplantation.

CONCLUSION: Our findings show that LINC01296 can alleviate the injury induced by cerebral ischemia and reimplantation by preventing the inhibitory effect of miR-29c on Birc2 and Bak1. Our research also provides new strategies and goals for the clinical treatment of patients with cerebral ischemia?reperfusion. Keywords : LNC01296, miRNA-29c, Apoptotic gene, Cerebral ischemia?reperfusion injury, Neuroprotection

Corresponding author : Lingjie MENG, menglingjiee@126.com