Turkish Neurosurgery 2022 , Vol 32 , Num 4
The Alteration of Neurogenesis and Pathological Markers in Alzheimer's Disease After Deep Brain Stimulation
1Ondokuz Mayıs University, School of Medicine, Neuromodulation Center, Samsun, Turkey
2Ondokuz Mayıs University, School of Medicine, Department of Neurosurgery, Samsun, Turkey
3Mental Health and Neuroscience, Maastricht University Medical Center, Department of Neurosurgery, Maastricht, The Netherlands
DOI : 10.5137/1019-5149.JTN.35598-21.2 Alzheimer's disease (AD) is the most common type of dementia that causes disabilities in memory formation and activities of daily living. Unfortunately, pharmacologic treatments have minimal and short-lasting effects on AD. With the increasing aging population, investigations into therapeutic strategies for AD that lead to a delay in disease progression would significantly reduce the global burden of AD. Deep brain stimulation (DBS) is considered therapeutic for several conditions, such as movement disorders and some psychiatric diseases. Preclinical and clinical studies that used DBS as a treatment modality demonstrate the safety of DBS in AD and suggest potential memory improvements after surgery. Nevertheless, more studies are needed to understand the therapeutic mechanism of DBS. In this review, we summarize studies on DBS in various targets for AD and discuss DBS-induced changes in neurogenesis and pathological markers in AD. Keywords : Alzheimer's disease, Deep brain stimulation, Neurogenesis, Neuroprotection
Corresponding author : Ersoy KOCABICAK, ersoykocabicak@gmail.com