Turkish Neurosurgery 2020 , Vol 30 , Num 1
Increased Expression of GRP78 Correlates with Adverse Outcome in Recurrent Glioblastoma Multiforme Patients
Xue WEN1,Xuan CHEN1,Xiaoping CHENG1
1Hubei Polytechnic Institute, School of Nursing, Department of Basic Medical, Xiaogan 432000, China DOI : 10.5137/1019-5149.JTN.21840-17.4 AIM: To evaluate the over expression of Glucose-regulated protein 78 kda (GRP78) in recurrent glioblastoma multiforme (GBM) and explore its chemoresatance.

MATERIAL and METHODS: Western blot analysis and real-time PCR were done to detect the expression of GRP78 in GBM tissues.

RESULTS: It was detected that GRP78 is up-expressed in GBM, especially in recurrent GBM. Radiotherapy (RT) plus temozolomide chemotherapy after primary tumor removal in relapsed patients induces C/EBP homologous protein (CHOP).

CONCLUSION: The results mentioned above illustrate an essential function of GRP78 in the pathogenesis of GBM and suggest this receptor as the latest prognostic marker for further GRP78-targeted molecular cancer therapy and potential diagnosis of GMB. Keywords : Glioma, Temozolomide, Glucose-regulated protein 78 kda, Chemotherapy

Corresponding author : Xue WEN, wenxue791203@163.com