Turkish Neurosurgery 2019 , Vol 29 , Num 3
Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson’s Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus
Dursun AYGUN1,Umit Akin DERE2,Onur YILDIZ1,Yasin TEMEL4,Ersoy KOCABICAK3
1Ondokuz Mayis University, Department of Neurology, Samsun, Turkey
2Baskent University, Department of Neurosurgery, Ankara, Turkey
3Ondokuz Mayis University, Department of Neurosurgery, Samsun, Turkey
4Maastricht University, Departments of Neurosurgery and Translational Neuroscience, Maastricht, Netherlands
DOI : 10.5137/1019-5149.JTN.24348-18.3 AIM: To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson’s disease (PD) who underwent deep brain stimulation of the subthalamic nucleus.

MATERIAL and METHODS: MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation.

RESULTS: MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p<0.05). Tremor scores improved by 31.5% (L) and by 14.2% (R) (p<0.05), rigidity scores improved by 17.3% (L) and by 14.2% (R) (p<0.05) and bradykinesia scores improved by 20.6% (L) and by 11.5% (R) (p<0.05) from baseline. There was no significant difference between MLE and the number of microelectrodes used (p> 0.05).

CONCLUSION: MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure. Keywords : Parkinson′s disease, Subthalamic nucleus, Deep brain stimulation, Microelectrode recording, Microlesion effect

Corresponding author : Umit Akin DERE, umitakindere@gmail.com