Turkish Neurosurgery 2018 , Vol 28 , Num 6
Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury
Salim SENTURK1,Mesut Emre YAMAN2,Hasan Emre AYDIN3,Guven GUNEY5,Ismail BOZKURT6,Kemal PAKSOY7,Ahmet Atilla ABDIOGLU8
1Koc University Hospital, Department of Neurosurgery, Istanbul, Turkey
2Memorial Hospital, Neurosurgery Clinic, Ankara, Turkey
3Dumlupinar University, Department of Neurosurgery, Kutahya, Turkey
4Osmangazi University, Department of Pharmacology, Eskisehir, Turkey
5Hitit University, Research and Training Hospital, Department of Pathology, Corum, Turkey
6Cankiri State Hospital, Neurosurgery Clinic, Cankiri, Turkey
7Kackar State Hospital, Neurosurgery Clinic, Rize, Turkey
8Recep Tayyip Erdogan University, Department of Orthopaedic Surgery, Rize, Turkey
DOI : 10.5137/1019-5149.JTN.21829-17.3 AIM: To determine the effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury (SCI).

MATERIAL and METHODS: Eighteen Sprague-Dawley rats were randomly divided into three groups. All groups underwent thoracic laminectomy. The first group received no other intervention. The second and third groups suffered SCI via the aneurysm clip compression method, and additionally the third group received resveratrol. After euthanizing the rats, immunohistochemical analysis and biochemical parameters of tumor necrosis factor alpha (TNF-?) and interleukin (IL)-1? were measured.

RESULTS: The resveratrol group had statistically significant lower levels of TNF-?, IL -1?, and terminal deoxynucleotidyl transferasemediated dUTP nick-end labeling (TUNEL) positive cells and higher number of glial and motor neuron cells.

CONCLUSION: Resveratrol proves to have remarkable neuroprotective effects on SCI in an experimental model in addition to its proven cardioprotective effects. Keywords : Neuroprotection, Neuroregeneration, Rat, Resveratrol, Spinal cord injury, TUNEL

Corresponding author : Ismail BOZKURT, ibozkurt85@gmail.com