Turkish Neurosurgery 1989 , Vol 1 , Num 1
ELECTRON MICROSCOPIC OBSERVATIONS OF THE EFFECTS OF DEXAMETHASONE AND MANNITOL IN THE HYPOXIC-ISCHEMIC RAT BRAIN (PART· I)
Sabahattin ÇOBANOĞLU1, Türkan ERBENGİ2
1Trakya University Medical Faculty. Department of Neurosurgery – EDİRNE
2Istanbul Medical Faculty. Department of Histology and Embryology - İSTANBUL
In a modified LEVINE preparation, the effects of mannitol dexamethasone alone and in combination in hypoxic-ischemic brain insults were studied by electron microscopy in which dexamethasone appeared to be more effective than mannitol or its combination with mannitol in reducing ischemic swelling and protecting the neural integrity. Keywords : Rat, Electron microscopy, Ischemic edema, Dexamethasone, Mannitol