Turkish Neurosurgery 2012 , Vol 22 , Num 6
The Effect of Bevacizumab on Spinal Epidural Fibrosis in a Postlaminectomy Rat Model
Mete KARATAY1, Yavuz ERDEM1, Ender KOKTEKIR2, Yavuz Selim ERKOC1, Muzaffer CAYDERE3, Mehmet Akif BAYAR1
1Ministry of Health, Ankara Training and Research Hospital, Department of Neurosurgery, Ankara, Turkey
2Selcuk University, Faculty of Medicine, Department of Neurosurgery, Konya, Turkey
3Ministry of Health, Ankara Training and Researh Hospital, Department of Pathology, Ankara, Turkey
DOI : 10.5137/1019-5149.JTN.6155-12.1 AIM: Spinal epidural fibrosis is an inherent result of surgical trauma after laminectomy. The conditions in which epidural fibrosis is excessive are in the etiology of failed back syndrome. There have been many attempts to prevent formation of epidural fibrosis. Bevacizumab which is an anti-angiogenic medication, inhibits the effect of VEGF and thereby decreases the new blood vessel formation and as a result prevents adhesions. This study shows the effect of bevacizumab on spinal epidural fibrosis developing after laminectomy in rats.

MATERIAL and METHODS: In this study, 20 Wistar rats were used. Rats were divided into two groups; a control group, and a bevacizumab group. Three-level laminectomy was performed on the rats. Rats in the control group only had the laminectomy. In the bevacizumab group, 2.5 mg/kg bevacizumab diluted in 0.9% NaCl with a factor of 1:10 impregnated on cotton was applied on the dura topically for 5 minutes. Three weeks later, rats were sacrificed for histopathologic examination. Epidural fibrosis tissue was graded following sacrifice.

REAULTS: Statistically, it was found that the bevacizumab group had significantly less epidural fibrosis compared to the control group (p<0.05).

CONCLUSION: Bevacizumab reduced the spinal epidural fibrosis significantly that developed in rats after laminectomy via its anti-VEGF effect by blocking VEGF receptors. Keywords : Spinal epidural fibrosis, Failed back syndrome, Laminectomy, Bevacizumab, VEGF (vascular endothelial growth factor)

Corresponding author : Mete Karatay, lexel26@hotmail.com