Turkish Neurosurgery 2012 , Vol 22 , Num 5
Early Brain Injury Following Aneurysmal Subarachnoid Hemorrhage: Emphasis on Cellular Apoptosis
Simge YUKSEL1, Yusuf Berk TOSUN1, Julian CAHILL2, Ihsan SOLAROGLU3
1Koç University, Faculty of Medicine, Neuroscience Research Lab., Sariyer, Istanbul, Turkey
2University Hospitals Coventry and Warwickshire, Department of Neurosurgery, Coventry, United Kingdom
3Koç University, Faculty of Medicine, Department of Neurosurgery, Sariyer, Istanbul, Turkey
DOI : 10.5137/1019-5149.JTN.5731-12.1 Subarachnoid hemorrhage (SAH) due to intracranial aneurysm rupture is a complex clinical disease with high mortality and morbidity. Recent studies suggest that early brain injury (EBI) rather than vasospasm might be responsible for morbidity and mortality within 24-72 hours after SAH. The rise in intracranial pressure following SAH causes a significant drop in cerebral perfusion pressure that leads to global cerebral ischemia and initiates the acute injury cascade. Various molecular mechanisms have been shown to involve in the pathophysiology of EBI including cellular apoptosis. In this review, we summarize apoptotic molecular mechanisms involved in the etiology of EBI and its potential as a target for future therapeutic intervention. Keywords : Apoptosis, Early brain injury, p53, Stroke, Subarachnoid hemorrhage
Corresponding author : Ihsan Solaroglu, isolaroglu@ku.edu.tr