LNC01296 Regulates Apoptosis Genes Birc2 and Bak1 by Targeting miRNA-29c and Participates in Neuroprotection During Cerebral Ischemia/Reperfusion Injury in Rats

Lingjie MENG; Yuanpu QI; Ke DU; Xiaoyu ZHANG

doi:10.5137/1019-5149.JTN.36564-21.1

Issue release date: 12.11.2024

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Turkish Neurosurgery 2023 , Vol 33 , Num 1

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LNC01296 Regulates Apoptosis Genes Birc2 and Bak1 by Targeting miRNA-29c and Participates in Neuroprotection During Cerebral Ischemia/Reperfusion Injury in Rats

Lingjie MENG¹,Yuanpu QI¹,Ke DU¹,Xiaoyu ZHANG²

¹Zhengzhou Railway Vocational and Technical College, Rehabilitation and Treatment Major, Zhengzhou, Henan, China
²Fuzhou Medical College of Nanchang University, Fuzhou, Jiangxi, China DOI : 10.5137/1019-5149.JTN.36564-21.1 AIM: To explore the extent to which LNC01296 inhibits the miRNA-29c expansion genes Birc2 and Bak1 from causing damage induced by brain expansion and reimplantation.

MATERIAL and METHODS: A total of 120 adult male experimental rats were divided to verify the effects of miRNA-29c and LNC01296 on brain expansion/reimplantation injury.

RESULTS: miRNA-29c can inhibit the Birc2/Bak1 pathway and aggravate the brain expansion/reimplantation damage. LNC01296 blocks miRNA-29c from entering the brain to protect it from expansion after reimplantation.

CONCLUSION: Our findings show that LINC01296 can alleviate the injury induced by cerebral ischemia and reimplantation by preventing the inhibitory effect of miR-29c on Birc2 and Bak1. Our research also provides new strategies and goals for the clinical treatment of patients with cerebral ischemia?reperfusion. Keywords : LNC01296, miRNA-29c, Apoptotic gene, Cerebral ischemia?reperfusion injury, Neuroprotection

Corresponding author : Lingjie MENG, menglingjiee@126.com